Quorum sensing and quorum-quenching enzymes.
Quorum sensing and quorum-quenching enzymes.
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DOI：
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发表时间：
2005-02
影响因子：
3
通讯作者：
Yi-hu Dong;Lian-Hui Zhang
中科院分区：
文献类型：
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作者：
Yi-hu Dong;Lian-Hui Zhang
为了在竞争环境中获得最大利益，单细胞细菌采用了一种称为群体感应（QS）的群落遗传调节机制。许多细菌使用QS信号系统来同步靶基因表达并在局部群体中协调生物活性。N-酰基高丝氨酸内酯（N-acylhomoserine lactones，AHLs）是革兰氏阴性菌中一类重要的QS信号家族，具有重要的生物学功能，包括毒力和生物膜形成。最近在一系列生物体中，包括细菌和真核生物中发现了几组AHL降解酶。这些酶在AHL依赖性病原体和转基因植物中的表达有效地淬灭微生物QS信号传导并阻断病原体感染。这些新的群体淬灭酶的发现不仅为控制细菌感染提供了一种有前途的手段，而且也为研究它们在宿主生物中的作用及其对生态系统的潜在影响提出了新的挑战。
To gain maximal benefit in a competitive environment, single-celled bacteria have adopted a community genetic regulatory mechanism, known as quorum sensing (QS). Many bacteria use QS signaling systems to synchronize target gene expression and coordinate biological activities among a local population. N-acylhomoserine lactones (AHLs) are one family of the well-characterized QS signals in Gram-negative bacteria, which regulate a range of important biological functions, including virulence and biofilm formation. Several groups of AHL-degradation enzymes have recently been identified in a range of living organisms, including bacteria and eukaryotes. Expression of these enzymes in AHL-dependent pathogens and transgenic plants efficiently quenches the microbial QS signaling and blocks pathogenic infections. Discovery of these novel quorum quenching enzymes has not only provided a promising means to control bacterial infections, but also presents new challenges to investigate their roles in host organisms and their potential impacts on ecosystems.