Targeted ablation of cardiac sympathetic neurons attenuates adverse postinfarction remodelling and left ventricular dysfunction
Targeted ablation of cardiac sympathetic neurons attenuates adverse postinfarction remodelling and left ventricular dysfunction
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DOI：
10.1113/ep086928
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发表时间：
2018-08
影响因子：
2.7
通讯作者：
Liang Xiong;Yu Liu;Mingmin Zhou;Guangji Wang;Dajun Quan;Wei Shuai;Caijie Shen;Bin Kong;Congxin Huang;He Huang
中科院分区：
文献类型：
--
作者：
Liang Xiong;Yu Liu;Mingmin Zhou;Guangji Wang;Dajun Quan;Wei Shuai;Caijie Shen;Bin Kong;Congxin Huang;He Huang
这项研究的中心问题是什么？靶向消融心脏交感神经元能否抑制心肌梗死诱导的不良心脏重构和左心室功能障碍？主要发现是什么及其重要性？靶向消融心脏交感神经元可明显减轻交感神经重构和神经内分泌激活，减轻心肌肥厚和纤维化，改善左心室功能。因此，靶向消融心脏交感神经元可能对不良的梗死后重构和左心室功能障碍有有益的影响。
What is the central question of this study? Can targeted ablation of cardiac sympathetic neurons suppress myocardial infarction‐induced adverse cardiac remodelling and left ventricular dysfunction? What is the main finding and its importance? Targeted ablation of cardiac sympathetic neurons significantly alleviated sympathetic remodelling and neuroendocrine activation, attenuated cardiac hypertrophy and fibrosis and improved left ventricular function. Thus, targeted ablation of cardiac sympathetic neurons might have a beneficial effect on adverse postinfarction remodelling and left ventricular dysfunction.