Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury
Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury
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DOI：
10.1093/brain/awq174
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发表时间：
2010-08-01
期刊：
影响因子：
14.5
通讯作者：
Maestu, Fernando
中科院分区：
文献类型：
--
作者：
Castellanos, Nazareth P.;Paul, Nuria;Maestu, Fernando
认知过程需要专门的多个，本地和远程大脑区域之间的功能相互作用。虽然这些相互作用可以被获得性脑损伤强烈改变，但大脑可塑性允许网络重组主要负责恢复。目前的工作评估脑损伤对功能连接模式的影响。利用标准频带内的小波相干性，对15例脑损伤患者和14例健康对照者的静息态脑磁图记录进行了网络计算。我们比较了定义网络的参数，例如相互作用的数量和强度以及它们的拓扑结构，在两种情况下：创伤性脑损伤和康复治疗后。δ和θ为基础的连接性的损失，相反，在α和β带为基础的连接性的增加被发现。此外，连接性参数接近控制在所有频段，特别是在慢波段。网络重组和认知恢复之间的相关性被发现：基于δ-带的连接的减少和基于α-带的连接的增加分别与言语流畅性分数以及知觉组织和工作记忆指数相关。此外，基于θ和β带的连接值的变化与患者能力评定量表相关。本研究为脑损伤后神经元可塑性过程的神经生理机制提供了新的证据，并表明这些变化与行为水平上观察到的变化有关。
Cognitive processes require a functional interaction between specialized multiple, local and remote brain regions. Although these interactions can be strongly altered by an acquired brain injury, brain plasticity allows network reorganization to be principally responsible for recovery. The present work evaluates the impact of brain injury on functional connectivity patterns. Networks were calculated from resting-state magnetoencephalographic recordings from 15 brain injured patients and 14 healthy controls by means of wavelet coherence in standard frequency bands. We compared the parameters defining the network, such as number and strength of interactions as well as their topology, in controls and patients for two conditions: following a traumatic brain injury and after a rehabilitation treatment. A loss of delta- and theta-based connectivity and conversely an increase in alpha- and beta-band-based connectivity were found. Furthermore, connectivity parameters approached controls in all frequency bands, especially in slow-wave bands. A correlation between network reorganization and cognitive recovery was found: the reduction of delta-band-based connections and the increment of those based on alpha band correlated with Verbal Fluency scores, as well as Perceptual Organization and Working Memory Indexes, respectively. Additionally, changes in connectivity values based on theta and beta bands correlated with the Patient Competency Rating Scale. The current study provides new evidence of the neurophysiological mechanisms underlying neuronal plasticity processes after brain injury, and suggests that these changes are related with observed changes at the behavioural level.