Calcineurin: Not just a simple protein phosphatase
Calcineurin: Not just a simple protein phosphatase
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DOI：
10.1006/bbrc.1997.6802
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发表时间：
1997-06-18
影响因子：
3.1
通讯作者：
Guerini, D
中科院分区：
文献类型：
--
作者：
Guerini, D
钙调神经磷酸酶是一种 Ca2+ 钙调蛋白依赖性蛋白磷酸酶，在细胞内 Ca2+ 信号传导的控制中具有重要作用。该蛋白质是一个催化 (CnA) 亚基和一个调节 (CnB) 亚基的异二聚体。正如蛋白质序列所示和晶体结构所证实的那样，钙调神经磷酸酶（CnA）的催化亚基与其他蛋白磷酸酶具有高度同源性。调节亚基 (CnB) 属于 EP-hand Ca2+ 结合蛋白家族。尽管它与钙调蛋白相似，但它具有不同的三级结构。钙调神经磷酸酶是两种重要的免疫抑制药物的靶标：环孢菌素 A 和 FK506。随后，详细阐明了钙调神经磷酸酶在细胞因子介导的 T 细胞激活中的作用。对钙调磷酸酶在其他细胞（特别是神经元）中的作用的理解也在迅速进展。 (C) 1997 年学术出版社。
Calcineurin is a Ca2+ calmodulin dependent protein phosphatase which has an important role in the control of intracellular Ca2+ signalling. The protein is a heterodimer of one catalytic (CnA) subunit and one regulatory (CnB) subunit. As suggested by the protein sequence and confirmed by the crystallographic structure, the catalytic subunit of calcineurin (CnA) has high homologies with other protein phosphatases. The regulatory subunit (CnB) belongs to the EP-hand Ca2+ binding protein family. Despite its similarity with calmodulin, it has a different tertiary structure. Calcineurin is the target of two important immunosuppressant drugs: cyclosporin A and FK506. Subsequently, a detailed clarification of the role of calcineurin in the cytokine mediated activation of the T-cells has been possible. The understanding of the role of calcineurin in other cells, in particular neurons, is also progressing rapidly. (C) 1997 Academic Press.