Hospital visits among women with skeletal-related events secondary to breast cancer and bone metastases: a nationwide population-based cohort study in Denmark.
Hospital visits among women with skeletal-related events secondary to breast cancer and bone metastases: a nationwide population-based cohort study in Denmark.
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DOI：
10.2147/clep.s42325
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发表时间：
2013
影响因子：
3.9
通讯作者：
Fryzek JP
中科院分区：
文献类型：
--
作者：
Svendsen ML;Gammelager H;Sværke C;Yong M;Chia VM;Christiansen CF;Fryzek JP
乳腺癌妇女的骨骼相关事件（SREs）可能与大量使用保健资源有关。我们对丹麦妇女继发于乳腺癌和骨转移的SREs的住院和门诊就诊情况进行了研究。我们确定了2003年至2009年间首次发生骨转移的乳腺癌患者，这些患者随后发生了SRE（定义为病理性骨折、脊髓压迫、放射治疗或骨手术）。医院就诊包括住院次数、住院时间、医院门诊就诊次数和急诊室就诊次数。对SRE前（诊断期前90天）、诊断期（SRE前14天）和SRE后（SRE后90天）的医院就诊次数进行了评估。在SRE后90天内经历一次以上SRE的患者被定义为多次SRE，并被随访至最后一次SRE后90天。我们确定了569例继发于乳腺癌并伴有骨转移的SREs患者。大多数女性有多发SREs（73.1%）。分别有20.9%和33.4%的单次和多次sre的妇女在sre后死亡。无论SREs的数量和类型如何，在诊断期间，SREs与大量的医院就诊有关。与单次SRE患者相比，多次SRE患者在SRE后的就诊次数通常更高，例如，单次SRE患者的住院时间中位数为5天（四分位数范围0-15），而多次SRE患者的住院时间中位数为13天（四分位数范围4-30）。继发于乳腺癌和骨转移的SREs与大量使用医院资源有关。
Skeletal-related events (SREs) among women with breast cancer may be associated with considerable use of health-care resources. We characterized inpatient and outpatient hospital visits in a national population-based cohort of Danish women with SREs secondary to breast cancer and bone metastases. We identified first-time breast cancer patients with bone metastases from 2003 through 2009 who had a subsequent SRE (defined as pathologic fracture, spinal cord compression, radiation therapy, or surgery to bone). Hospital visits included the number of inpatient hospitalizations, length of stay, number of hospital outpatient clinic visits, and emergency room visits. The number of hospital visits was assessed for a pre-SRE period (90 days prior to the diagnostic period), a diagnostic period (14 days prior to the SRE), and a post-SRE period (90 days after the SRE). Patients who experienced more than one SRE during the 90-day post-SRE period were defined as having multiple SREs and were followed until 90 days after the last SRE. We identified 569 women with SREs secondary to breast cancer with bone metastases. The majority of women had multiple SREs (73.1%). A total of 20.9% and 33.4% of women with single and multiple SREs died in the post-SRE period, respectively. SREs were associated with a large number of hospital visits in the diagnostic period, irrespective of the number and type of SREs. Women with multiple SREs generally had a higher number of visits compared to those with a single SRE in the post-SRE period, eg, median length of hospitalization was 5 days (interquartile range 0–15) for women with a single SRE and 13 days (interquartile range 4–30) for women with multiple SREs. SREs secondary to breast cancer and bone metastases were associated with substantial use of hospital resources.