Urinary 8-hydroxy-2′-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure
Urinary 8-hydroxy-2′-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure
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DOI：
10.1093/eurjhf/hfq178
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发表时间：
2011-01-01
影响因子：
18.2
通讯作者：
Matsuzaki, Masunori
中科院分区：
文献类型：
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作者：
Kobayashi, Shigeki;Susa, Takehisa;Matsuzaki, Masunori
氧化应激在心力衰竭（HF）的发病机制中起着至关重要的作用。我们研究了尿8-羟基-2 '-脱氧鸟苷（8-OHdG），氧化DNA损伤的产物，是否是慢性心力衰竭（CHF）的严重程度和氧化应激水平在failinghearts.Methods和结果的临床有用的生物标志物。我们测量了8-OHdG的血清中获得的冠状窦（CS）和主动脉根（Ao）在小组的对照组和CHF患者。然后，我们测量了31名对照受试者和194名CHF患者的尿8-OHdG和其他生物标志物（脑利钠肽、8-异前列腺素、高敏C反应蛋白、白细胞介素-6和肿瘤坏死因子-a）[左心室射血分数（LVEF）：28.3 +/- 8.1%]。仅CHF患者CS血清8-OHdG显著高于Ao。CHF患者尿8-OHdG也显著高于对照组，尿8-OHdG随纽约心脏协会分级升高而升高。此外，尿8-OHdG与LVEF（r = -0.27）、肺毛细血管楔压（r = -0.31）和左室舒张末期容积指数（r = -0.22）显著相关。结论在HF患者中，尿8-OHdG可反映氧化应激水平以及与CHF症状状态和功能严重程度相关的各种参数。
Aims Oxidative stress is known to play a crucial role in the pathogenesis of heart failure (HF). We investigated whether urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidative DNA damage, is a clinically useful biomarker of the severity of chronic heart failure (CHF) and oxidative stress levels in failing hearts.Methods and results We measured 8-OHdG in the serum obtained from the coronary sinus (CS) and aortic root (Ao) in small groups of control subjects and CHF patients. We then measured urinary 8-OHdG and other biomarkers (brain natriuretic peptide, 8-isoplastane, high-sensitivity C-reactive protein, interleukin-6, and tumour necrosis factor-a) in 31 control subjects and 194 patients with CHF [left-ventricular ejection fraction (LVEF): 28.3 +/- 8.1%]. Serum 8-OHdG was significantly higher in the CS than the Ao in CHF patients only. Urinary 8-OHdG was also significantly higher in CHF patients than in control subjects, and urinary 8-OHdG became higher as New York Heart Association class increased. Moreover, there was a significant correlation between urinary 8-OHdG and LVEF (r = -0.27), pulmonary capillary wedge pressure (r = -0.31), or left-ventricular end-diastolic volume index (r = -0.22). In contrast, there was poor correlation between the severity of CHF and the other neurohumoral biomarkers.Conclusion In HF, urinary 8-OHdG seems to reflect the level of oxidative stress and various parameters related to symptomatic status and functional severity of CHF.