Transcranial magnetic stimulation during British Sign Language production reveals monitoring of discrete linguistic units in left superior parietal lobule
Transcranial magnetic stimulation during British Sign Language production reveals monitoring of discrete linguistic units in left superior parietal lobule
复制标题
DOI：
10.1101/679340
复制
发表时间：
2019-06
期刊：
影响因子：
--
通讯作者：
D. Vinson;Neil Fox;J. Devlin;K. Emmorey;G. Vigliocco
中科院分区：
文献类型：
--
作者：
D. Vinson;Neil Fox;J. Devlin;K. Emmorey;G. Vigliocco
成功的人类手部和手臂运动通常通过在计划、启动、预测和控制中结合视觉、运动和本体感受信息来进行。上级顶叶（SPL）已被认为在整合视觉和运动信息，特别是在抓取物体和其他此类任务，优先视觉信息的关键作用。然而，手语生产也从事SPL，即使流利的签名不视觉跟踪他们的手或固定在目标位置。手语的产生仅仅依赖于视觉引导动作中的运动/本体感受过程，还是手语的独特特征改变了这些过程？15名流利的英国手语用户命名的图片，而我们管理经颅磁刺激（TMS）左SPL，控制网站，或没有TMS。TMS对SPL有非常具体的影响：复杂的双手手势（需要手接触的手势）的（基于手势的）语音替代错误率增加，但TMS并没有减缓或以其他方式损害性能。因此，TMS降低了在成功的双手协调过程中检测或纠正语音错误的可能性，但它并没有明显改变精细的运动控制。这些研究结果证实，流畅的签名SPL已适应监测电机计划离散的手配置从内存中检索，以及更细粒度的方面的视觉引导的行动。
Successful human hand and arm movements are typically carried out by combining visual, motoric, and proprioceptive information in planning, initiation, prediction, and control. The superior parietal lobule (SPL) has been argued to play a key role in integrating visual and motoric information particularly during grasping of objects and other such tasks which prioritise visual information. However, sign language production also engages SPL even though fluent signers do not visually track their hands or fixate on target locations. Does sign language production simply rely on the motoric/ proprioceptive processes engaged in visually guided action, or do the unique characteristics of signed languages change these processes? Fifteen fluent British Sign Language users named pictures while we administered transcranial magnetic stimulation (TMS) to left SPL, a control site, or no TMS. TMS to SPL had very specific effects: an increased rate of (sign-based) phonological substitution errors for complex two-handed signs (those requiring hand contact), but TMS did not slow or otherwise impair performance. Thus, TMS decreased the likelihood of detecting or correcting phonological errors during otherwise successful bimanual coordination, but it did not noticeably alter fine movement control. These findings confirm that for fluent signers SPL has adapted to monitor motor plans for discrete hand configurations retrieved from memory as well as more fine-grained aspects of visually guided actions.