Efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for acute myeloid leukemia: A protocol for a Bayesian network meta-analysis.
Efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for acute myeloid leukemia: A protocol for a Bayesian network meta-analysis.
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DOI：
10.1097/md.0000000000026098
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发表时间：
2021-06-11
期刊：
影响因子：
1.6
通讯作者：
Xu R
中科院分区：
文献类型：
--
作者：
Yin X;Ding Y;Yu L;Guo C;Cui Y;Zhai X;Wang Y;Ding S;Shen M;Li Z;Xu R
急性髓系白血病（AML）是最常见的造血系统恶性肿瘤，严重威胁患者的生命。大多数AML患者起病急、病情重、预后差。本研究旨在通过贝叶斯网络荟萃分析（NMA）综合评价化疗联合不同剂量白细胞介素2（IL-2）维持治疗治疗AML的有效性和安全性。自发起至2021年10月，我们将检索PubMed、Cochrane Library、CNKI、Embase等数据库，全面收集化疗联合不同剂量IL-2维持治疗治疗AML的随机对照试验（RCT）。两名独立研究人员将根据纳入和排除标准完成文献筛选和数据提取，然后独立对所有证据进行偏倚风险评估。贝叶斯 NMA 用于综合评估所有证据。使用STATA16.0和WinBUGS1.4.3软件处理和分析所有数据，并根据建议评估、制定和评估的分级对NMA中的证据质量进行分类。该研究将评估化疗联合不同剂量IL-2维持治疗对AML的疗效和安全性。该研究将为化疗联合不同剂量IL-2维持治疗治疗AML的有效性和安全性提供依据。我们希望这项研究能为临床医生和患者提供有意义的支持。 IPLASY202140106 由于该研究基于已发表或注册的随机对照试验，因此放弃了伦理批准和患者知情同意。
Acute myeloid leukemia (AML) is the most common malignant tumor of the hematopoietic system, which seriously threatens the lives of patients. Most AML patients have acute onset, severe condition, and poor prognosis. The present study aimed to comprehensively evaluate the effectiveness and safety of chemotherapy combined with different doses of interleukin-2 (IL-2) maintenance treatments in AML by Bayesian network meta-analysis (NMA). From its inception until October 2021, we will search PubMed, Cochrane Library, CNKI, Embase, and other databases to comprehensively collect randomized controlled trials (RCTs) of chemotherapy combined with different doses of IL-2 maintenance therapies for AML. Two independent researchers will complete the literature screening and data extraction according to the inclusion and exclusion criteria, and then independently conduct a bias risk assessment of all the evidence. Bayesian NMA was used to evaluate all the evidence comprehensively. Use STATA16.0 and WinBUGS1.4.3 software to process and analyze all data, and classify the quality of evidence in NMA according to grading of recommendations assessment, development, and evaluation. The study will evaluate the efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for AML. The study will provide a basis for the efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for AML. We hope that this study can provide meaningful support for clinicians and patients. INPLASY202140106 Since the study is based on published or registered RCTs, ethical approval and patient informed consent are abandoned.