Neural substrate for the effects of passive training on sensorimotor cortical representation: A study with functional magnetic resonance imaging in healthy subjects
Neural substrate for the effects of passive training on sensorimotor cortical representation: A study with functional magnetic resonance imaging in healthy subjects
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DOI：
10.1097/00004647-200003000-00006
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发表时间：
2000-03-01
影响因子：
6.3
通讯作者：
Chollet, F
中科院分区：
文献类型：
--
作者：
Carel, C;Loubinoux, I;Chollet, F
重复被动运动是大多数康复程序的一部分，特别是对中风和运动缺陷患者。然而，关于反复的本体感觉刺激对人类脑内感觉运动网络的影响，我们所知甚少。12名健康受试者被招募，所有受试者都接受了两次功能磁共振成像（fMRI），间隔1个月。在两次功能磁共振成像之间的时间里，六名受试者进行了被动的日常运动训练。其余6名受试者未接受任何训练，作为对照组。功能磁共振成像（fMRI）中使用的任务是校准腕关节的重复被动屈伸，类似于训练中执行的任务。控制任务是休息。采用SPM96软件进行分析。图像被重新排列，平滑，并放入Talairach的神经解剖空间。在对照组中，通过比较第二阶段的激活与休息和第一阶段的激活与休息来评估重复任务的时间效应。然后，这个石灰效应被用作零假设来评估我们训练组中单独的训练效果。与休息相比，被动运动显示大部分参与运动控制的皮质区域被激活（即对侧初级感觉运动皮层，辅助运动区[SMA]，枕骨，同侧小脑Brodmann区40）。时间效应比较显示，初级感觉运动皮层和SMA活性降低，同侧小脑半球活性增加，符合习惯效应。训练增加了对侧初级感觉运动皮层和SMA的活动。观察到SMA活性的重新分布。作者证明，重复本体感觉刺激的被动训练可诱导健康受试者的感觉运动表征重组。这些变化发生在涉及运动准备和运动执行的皮质区域，代表了本体感觉训练的神经基础，这可能对接受康复治疗的患者有益。
Repetitive passive movements are part of most rehabilitation procedures, especially in patients with stroke and motor deficit. However, little is known about the consequences of repeated proprioceptive stimulations on the intracerebral sensorimotor network in humans. Twelve healthy subjects were enrolled, and all underwent two functional magnetic resonance imaging (fMRI) sessions separated by a 1-month interval. Passive daily movement training was performed in six subjects during the time between the two fMRI sessions. The other six subjects had no training and were considered as the control group. The task used during fMRI was calibrated repetitive passive flexion-extension of the wrist similar to those performed during training. The control task was rest. The darn were analyzed with SPM96 software. Images were realigned, smoothed, and put into Talairach's neuroanatomical space. The time effect from the repetition of the task was assessed in the control group by comparing activation versus rest in the second session with activation versus rest in the first session. This lime effect then was used as null hypothesis to assess the training effect alone in our trained group. Passive movements compared with rest showed activation of most of the cortical areas involved in motor control (i.e., contralateral primary sensorimotor cortex, supplementary motor area [SMA], cinguium, Brodmann area 40 ipsilateral cerebellum). Time effect comparison showed a decreased activity of the primary sensorimotor cortex and SMA anti an increased activity of ipsilateral cerebellar hemisphere, compatible with a habituation effect. Training brought about an increased activity of contralateral primary sensorimotor cortex and SMA. A redistribution of SMA activity was observed. The authors demonstrated that passive training with repeated proprioceptive stimulation induces a reorganization of sensorimotor representation in healthy subjects. These changes take place in cortical areas involved in motor preparation and motor execution and represent the neural basis of proprioceptive training, which might benefit patients undergoing rehabilitative procedures.