Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE). A case control study
Construction and validation of a simple scoring system for stage III colorectal cancer recurrence (SiS-SCORE). A case control study
复制标题
构建并验证 III 期结直肠癌复发的简单评分系统 (SiS-SCORE)。
DOI：
10.1093/jjco/hyy192
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发表时间：
2019
影响因子：
2.4
通讯作者：
Baba Hideo
中科院分区：
文献类型：
--
作者：
Ishikawa Shinji;Sawayama Hiroshi;Matsuo Akinobu;Uchino Ryojin;Honda Shinobu;Hirota Masahiko;Baba Hideo
背景Ⅲ期结直肠癌是辅助化疗的适应证，但对方案的选择尚无定论。如果可以预测复发，则可以作为选择治疗方案的指标。本研究的目的是预测复发的III期结直肠癌通过构建一个简单的评分system.MethodsThe第三阶段的情况下，接受根治性手术的信息，从两个设施和分析。一个评分系统的分析结果和评估的基础上，从不同facility.Results5个因素进行了多变量分析提取：年龄> 65岁，男性，直肠，≥ pN 2和CA 19 -9 > 37。当这些参数各评分为1分时，评分与累积复发率相关。按≤1分、2分、≥3分3组，5年复发率分别为：≤1分33.3%，2分42.1%，≥3分78.6%。≥3分者的累积复发率明显高于≤1分者（P< 0.001）。通过评价不同机构的病例获得了相似的结果（P= 0.032）。结论SiS-SCORE评分在不同设施中的结果一致，可推广应用。然而，需要一项前瞻性研究来证明SiS-SCORE的有用性。
BackgroundStage III colorectal cancer is an indication for adjuvant chemotherapy; however, there is no definite view on the selection of regimen. If the recurrence can be predicted, it can serve as the indicator of regimen selection. The present study aimed to predict the recurrence of stage III colorectal cancer by constructing a simple scoring system.MethodsThe information of stage III cases that underwent curative surgery was obtained from two facilities and analyzed. A scoring system was constructed from the analysis results and evaluated based on the cases from a different facility.ResultsFive factors were extracted by multivariate analysis: age > 65, male, rectum, ≥pN2 and CA19-9 > 37. When these parameters were scored as 1 point each, the score was correlated with the cumulative recurrence rate. Additionally, when cases were divided into three groups (≤1 point, 2 points, ≥3 points), the 5-year recurrence rate was as follows:, ≤1 point: 33.3%, 2 points: 42.1%, ≥3 points: 78.6%. The cumulative recurrence rate of ≥3 points was significantly higher than that of ≤1 point (P< 0.001). Similar results were obtained by evaluating that cases at a different facility (P= 0.032). Both cases with 2 points were located between ≤1 point and ≥3 points, reflecting the average recurrence rate of each institution.ConclusionAs the SiS-SCORE presented the same result in the facility that was different from the base facility, it can be used widely. However, a prospective study is required to prove the usefulness of the SiS-SCORE.