A structural and functional ground plan for neurons in the hindbrain of zebrafish
A structural and functional ground plan for neurons in the hindbrain of zebrafish
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DOI：
10.1073/pnas.1012185108
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发表时间：
2011-01-18
影响因子：
11.1
通讯作者：
Fetcho, Joseph
中科院分区：
文献类型：
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作者：
Kinkhabwala, Amina;Riley, Michael;Fetcho, Joseph
脊椎动物的后脑包含各种感觉运动网络，控制眼睛、下巴、头部和身体的运动。在这里，我们表明，条纹的神经元与共享的神经递质表型，延伸到整个年轻的斑马鱼后脑反映了广泛的潜在的结构和功能模式。神经递质条纹包含具有共同总体形态和转录因子标记的细胞类型。条纹内的神经元通过轴突投射的范围和位置、输入阻力和年龄系统地堆叠，并且在行为期间沿着条纹的轴被募集。这种模式的含义是，后脑中的许多网络是由一系列神经元组成的，这些神经元组成的条纹根据神经元的年龄、结构和功能特性以及行为角色从上到下排列。这个简单的组织可能构成了构建网络的基础，这些网络是由后脑产生的许多行为的基础。
The vertebrate hindbrain contains various sensory-motor networks controlling movements of the eyes, jaw, head, and body. Here we show that stripes of neurons with shared neurotransmitter phenotype that extend throughout the hindbrain of young zebrafish reflect a broad underlying structural and functional patterning. The neurotransmitter stripes contain cell types with shared gross morphologies and transcription factor markers. Neurons within a stripe are stacked systematically by extent and location of axonal projections, input resistance, and age, and are recruited along the axis of the stripe during behavior. The implication of this pattern is that the many networks in hindbrain are constructed from a series of neuronal components organized into stripes that are ordered from top to bottom according to a neuron's age, structural and functional properties, and behavioral roles. This simple organization probably forms a foundation for the construction of the networks underlying the many behaviors produced by the hindbrain.