LINKAGE OF A NASOPHARYNGEAL CARCINOMA SUSCEPTIBILITY LOCUS TO THE HLA REGION
LINKAGE OF A NASOPHARYNGEAL CARCINOMA SUSCEPTIBILITY LOCUS TO THE HLA REGION
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DOI：
10.1038/346470a0
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发表时间：
1990-08-02
期刊：
影响因子：
64.8
通讯作者：
DETHE, G
中科院分区：
文献类型：
--
作者：
LU, SJ;DAY, NE;DETHE, G
中国南方鼻咽癌的发病率几乎是大多数欧洲人群的100倍1。早期的研究表明，鼻咽癌的风险增加与HLA区域的特定单倍型有关：单倍型A2、Bw 46和抗原BIT的相对风险略高于2倍（参考文献2-4）。我们现在报告一个连锁研究的基础上受影响的同胞对这表明，基因紧密连锁的HLA位点赋予鼻咽癌的风险大大增加。最大似然估计的相对风险约为21。这种可疑的疾病易感基因（或基因）和已知的病毒和环境病因因素之间的关系仍有待阐明。
THE frequency of nasopharyngeal carcinoma is nearly 100-fold higher in southern Chinese than in most European populations1. Earlier studies have suggested that an increased risk of nasopharyngeal carcinoma is associated with specific haplotypes in the HLA region: relative risks slightly over twofold were found for haplotypes A2, Bw46 and the antigen BIT (refs 2–4). We now report a linkage study based on affected sib pairs which suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma. The maximum likelihood estimate is of a relative risk of approximately 21. The relationship between this suspected disease susceptibility gene (or genes) and known viral and environmental aetiological factors remains to be elucidated.