Plasmonic Vesicles of Amphiphilic Gold Nanocrystals: Self-Assembly and External-Stimuli-Triggered Destruction
Plasmonic Vesicles of Amphiphilic Gold Nanocrystals: Self-Assembly and External-Stimuli-Triggered Destruction
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DOI：
10.1021/ja204387w
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发表时间：
2011-07-20
影响因子：
15
通讯作者：
Duan, Hongwei
中科院分区：
文献类型：
--
作者：
Song, Jibin;Cheng, Lin;Duan, Hongwei
我们已经开发了一类新的等离子体泡状纳米结构组装从两亲性金纳米晶体与混合聚合物刷涂层。一个主要的发现是，金纳米晶体（纳米颗粒和纳米棒）与两种类型的化学上不同的聚合物接枝物（其整体上类似于嵌段共聚物）的整合产生了一种新型的混合构建块，其继承了嵌段共聚物的两亲性驱动的自组装以形成囊泡结构和纳米晶体的等离子体性质。与其他囊泡结构相反，等离子体囊泡的破坏可以由聚合物或聚乙烯醇固有的刺激机制触发。最近的进展，在纳米晶体合成和可控的表面引发聚合已经打开了丰富的可能性，将这一概念扩展到其他类型的纳米晶体和集成不同类型的纳米晶体到多功能囊泡。含有刺激响应聚合物的多功能囊泡的开发可以使其在生物传感，多模态成像和治疗诊断纳米医学中具有更广泛的应用。
We have developed a new class of plasmonic vesicular nanostructures assembled from amphiphilic gold nanocrystals with mixed polymer brush coatings. One major finding is that the integration of gold nanocrystals (nanoparticles and nanorods) with two types of chemically distinct polymer grafts, which are analogous to block copolymers as a whole, creates a new type of hybrid building block inheriting the amphiphilicity-driven self-assembly of block copolymers to form vesicular structures and the plasmonic properties of the nanocrystals. In contrast to other vesicular structures, the disruption of the plasmonic vesicles can be triggered by stimulus mechanisms inherent to either the polymer or the nanocrystal. Recent advances in nanocrystal synthesis and controlled surface-initiated polymerization have opened a wealth of possibilities for expanding this concept to other types of nanocrystals and integrating different types of nanocrystals into multifunctional vesicles. The development of multifunctional vesicles containing stimuli-responsive polymers could enable their broader applications in biosensing, multimodality imaging, and theragnostic nanomedicine.