NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation.
NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation.
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DOI：
10.4049/jimmunol.1004007
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发表时间：
2011-06-01
期刊：
影响因子：
--
通讯作者：
Levy BD
中科院分区：
文献类型：
--
作者：
Haworth O;Cernadas M;Levy BD
在包括哮喘在内的几种常见疾病中，免疫反应在病理上是持续的。为了确定适应性免疫反应的内源性促分解机制，我们使用了自限性过敏性呼吸道炎症的小鼠模型。停止接触变应原后，随着肺和纵隔淋巴结中自然杀伤(NK)细胞数量的增加，嗜酸性粒细胞和T细胞被清除。MLN NK细胞被激活，表达CD27、CD11b、CD69、CD107a和干扰素-γ。NK细胞耗竭扰乱了内源性分解程序，导致气道嗜酸性粒细胞和抗原特异性CD4+T细胞的清除延迟。NK细胞向炎症组织的转运依赖于CXCR3和CD62L。在分解过程中，嗜酸性粒细胞和抗原特异性的CD4+T细胞表达NKG2D配体和NKG2D受体的封闭抗体延迟了这些白细胞的清除。有趣的是，NK细胞表达CMKLR1，这是一种前分解调节因子RESOVIN E1的受体，而NK细胞的耗竭降低了RESOVIN E1介导的过敏性炎症的化解。解决素E1调节NK细胞体内迁移和体外杀伤作用。总之，这些发现表明了NK细胞在缓解期的新功能，NK细胞也可以在适应性免疫的分解中作为支持分解的介体的靶标。
Immune responses are pathologically sustained in several common diseases, including asthma. To determine endogenous pro-resolving mechanisms for adaptive immune responses, we used a murine model of self-limited allergic airway inflammation. After cessation of allergen exposure, eosinophils and T-cells were cleared concomitant with the appearance of increased numbers of natural killer (NK) cells in the lung and mediastinal lymph nodes (MLN). The MLN NK cells were activated, expressing CD27, CD11b, CD69, CD107a and IFN-γ. NK cell depletion disrupted the endogenous resolution program, leading to delayed clearance of airway eosinophils and antigen-specific CD4+ T cells. NK cell trafficking to inflamed tissues for resolution was dependent upon CXCR3 and CD62L. During resolution, eosinophils and antigen-specific CD4+ T cells expressed NKG2D ligands and a blocking antibody for the NKG2D receptor delayed clearance of these leukocytes. Of interest, NK cells expressed CMKLR1, a receptor for the pro-resolving mediator resolvin E1, and depletion of NK cells decreased resolvin E1-mediated resolution of allergic inflammation. Resolvin E1 regulated NK cell migration in vivo and NK cell cytotoxicity in vitro. Together, these findings indicate new functions in catabasis for NK cells that can also serve as targets for pro-resolving mediators in the resolution of adaptive immunity.
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影响因子：
82.9
作者：
Levy, BD;DeSanctis, GT;Serhan, CN
通讯作者：
Serhan, CN
影响因子：
4.4
作者：
Rabinovich, BA;Li, J;Miller, RG
通讯作者：
Miller, RG
影响因子：
30.5
作者：
Haworth, Oliver;Cernadas, Manuela;Levy, Bruce D.
通讯作者：
Levy, Bruce D.
DOI：
10.1084/jem.20092749
发表时间：
2010-08-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hao J;Liu R;Piao W;Zhou Q;Vollmer TL;Campagnolo DI;Xiang R;La Cava A;Van Kaer L;Shi FD
通讯作者：
Shi FD
DOI：
10.1152/ajplung.00327.2005
发表时间：
2006-08-01
影响因子：
4.9
作者：
Borchers, Michael T.;Harris, Nathaniel L.;Cosman, David
通讯作者：
Cosman, David