Evolution at the host-retrovirus interface
Evolution at the host-retrovirus interface
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DOI：
10.1002/bies.20504
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发表时间：
2006-12-01
期刊：
影响因子：
4
通讯作者：
Gifford, Robert J.
中科院分区：
文献类型：
--
作者：
Gifford, Robert J.
逆转录病毒在动物病毒中是不寻常的，因为它们能够整合到宿主基因组中并垂直传播给宿主后代。脊椎动物基因组包含许多不同的逆转录病毒衍生序列，反映了一个长期的共同进化历史，在这个历史中，基因组入侵反复发生，具有广泛的进化后果。在过去的10年里，一幅关于逆转录病毒多样性在脊椎动物基因组中的详细图景已经出现，揭示了不同物种之间显著不同的惊人和信息模式。这些数据对逆转录病毒的生物学和进化提供了深远的见解，最近的研究发现了野生种群中正在进行的基因组入侵，(1))以及对先天抗逆转录病毒防御的保守机制的描述，这些研究大大推进了这些数据的力量。(2、3)
Retroviruses are unusual amongst animal viruses in their capacity to integrate into host genomes and be transmitted vertically to host progeny. Vertebrate genomes contain numerous and diverse retrovirus-derived sequences reflecting a long co-evolutionary history during which genome invasion has occurred repeatedly, with wide-ranging evolutionary consequences. Over the past 10 years, a detailed picture of retroviral diversity throughout vertebrate genomes has emerged, revealing striking and informative patterns that differ markedly across species. The power of these data to deliver far-reaching insights into the biology and evolution of retroviruses has been significantly advanced by recent studies identifying ongoing genome invasion in wild populations,((1)) and by the characterisation of conserved mechanisms of innate antiretroviral defence.((2,3))