Modulation of c-myc expression in the HL-60 cell line.
Modulation of c-myc expression in the HL-60 cell line.
复制标题
HL-60 细胞系中 c-myc 表达的调节。
DOI：
10.1016/s0006-291x(84)80273-9
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发表时间：
1984
影响因子：
3.1
通讯作者：
Pitot,HC
中科院分区：
文献类型：
--
作者：
Grosso,LE;Pitot,HC
据报道，在二甲基亚砜或维甲酸诱导HL-60细胞向髓系分化的过程中，原癌基因myc的表达下降。在此，我们报道了几种聚腺苷二磷酸核糖聚合酶抑制剂诱导HL-60细胞的髓系分化。对c-myc基因在总细胞RNA群体中表达的研究表明，该基因的表达与培养细胞的分化状态(无论是髓系细胞还是单核细胞)呈负相关，与诱导剂和细胞增殖率无关。
A decrease in the expression of the myc proto-oncogene of HL-60 cells has been reported as an accompaniment of myeloid differentiation induced by either dimethylsulfoxide or retinoic acid. We report herein that several inhibitors of poly(ADP-ribose)-polymerase induced myeloid differentiation in HL-60 cultures. Studies on the expression of the c-myc gene in total cell RNA populations indicate that expression of this gene is inversely correlated with the state of differentiation, either myeloid or monocytic, of the cultured cells independent of the inducer and the rate of cell proliferation.