Single Center Retrospective Study of Patients with Ocular Mucous Membrane Pemphigoid (MMP)
Single Center Retrospective Study of Patients with Ocular Mucous Membrane Pemphigoid (MMP)
复制标题
眼粘膜类天疱疮（MMP）患者的单中心回顾性研究
DOI：
10.1080/09273948.2020.1783322
复制
发表时间：
2020
影响因子：
3.3
通讯作者：
R. Feldman
中科院分区：
文献类型：
--
作者：
M. Morel;T. DeGrazia;Laura Ward;Soroosh Behshad;H. Kim;R. Feldman
摘要目的粘膜类天疱疮（MMP）累及眼部常导致眼表疾病所致的毁灭性视力丧失。本研究旨在更好地描述临床症状、临床特征、临床进展的重要因素以及随时间推移的视力。方法对2012年1月1日至2017年7月1日在Emory眼科中心就诊的88例眼MMP患者进行回顾性病历分析。结果大部分MMP患者临床表现较晚。最常见的初始疾病并发症是穹窿部分或完全丧失和睑球粘连。临床稳定的时间通常发生在首次出现后1年。结论眼MMP是一种严重的疾病，常在晚期出现在三级医院，并导致眼睑和眼表的许多变化。这项研究表明，目前的临床症状是广泛的，视力的稳定需要几个月。
ABSTRACT Purpose Mucous membrane pemphigoid (MMP) with ocular involvement often leads to devastating vision loss from ocular surface disease. This study sought to better characterize presenting symptoms, clinical characteristics, important factors in clinical progression, and visual acuity over time. Methods A retrospective chart review was performed on 88 patients seen at the Emory Eye Center between January 1, 2012 and July 1, 2017 for ocular MMP. Results A large percentage of patients with MMP presented at later stages. Partial or complete loss of the fornices and symblepharon were the most common initial disease complications. The time to clinical stabilization usually occurred 1 year after initial presentation. Conclusions Ocular MMP is a devastating disease that often presents to tertiary care hospitals at late stages and leads to numerous eyelid and ocular surface changes. This study demonstrated that presenting clinical signs are broad and that stabilization of visual acuity takes months.