Transcriptional regulation of podocyte disease
Transcriptional regulation of podocyte disease
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DOI：
10.1016/j.trsl.2007.01.002
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发表时间：
2007-05-01
影响因子：
7.8
通讯作者：
Chugh, Sumant S.
中科院分区：
文献类型：
--
作者：
Chugh, Sumant S.
足细胞是高度特化的内脏上皮细胞，形成肾小球毛细血管袢的最外层，在维持肾小球滤过屏障中发挥关键作用。一些转录因子在正常和疾病条件下调节足细胞功能。在这篇综述中，概述了肾母细胞瘤 1 (WT1)、LIM 同源盒转录因子 1、β (Lmx1b)、pod1、pax-2、kreisler、核因子 kappa B (NF-kappa B)、smad7 以及锌指和同源盒 (ZHX) 蛋白在足细胞疾病发展中的作用。讨论了 ZHX 蛋白对几个重要足细胞基因（包括转录因子）的调节、它们在正常体内足细胞中的主要非核定位，以及与微小病变和局灶性和节段性肾小球硬化的发展相关的 ZHX 表达变化。最后，提出了一些未来肾小球疾病的治疗策略。
The podocyte is a highly specialized visceral epithelial cell that forms the outermost layer of the glomerular capillary loop and plays a critical role in the maintenance of the glomerular filtration barrier. Several transcriptional factors regulate the podocyte function under normal and disease conditions. In this review, the role of Wilms tumor 1 (WT1), LIM homeobox transcription factor 1, beta (Lmx1b), pod1, pax-2, kreisler, nuclear factor-kappa B (NF-kappa B), smad7, and zinc fingers and homeoboxes (ZHX) proteins in the development of podocyte disease is outlined. The regulation of several important podocyte genes, including transcriptional factors, by ZHX proteins, their predominant non-nuclear localization in the normal in vivo podocyte, and changes in ZHX expression related to the development of minimal change disease and focal and segmental glomerulosclerosis are discussed. Finally, some future therapeutic strategies for glomerular disease are proposed.