Microphthalmia-associated transcription factor, melanoma, and renal carcinoma: the small ubiquitin-like modifier connection.
Microphthalmia-associated transcription factor, melanoma, and renal carcinoma: the small ubiquitin-like modifier connection.
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小眼症相关转录因子、黑色素瘤和肾癌：小泛素样修饰剂连接。
DOI：
10.1111/j.1755-148x.2011.00925.x
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发表时间：
2011
影响因子：
4.3
通讯作者：
Yeh,EdwardTH
中科院分区：
文献类型：
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作者：
Yeh,EdwardTH
本文介绍了由Kevin Brown领导的对黑色素瘤家族先证者全基因组测序的研究。他们评估了他们的种系错义取代（E318K）和小眼症相关转录因子（MITF）。基于对31个家庭的连锁分析，研究人员发现，他们的比值对数（LOD）得分为2.7。研究的其他结果也被提及。
The article presents the study led by Kevin Brown on the whole proband genomic sequencing of families with melanoma. They evaluated their germline missense substitution (E318K) and microphthalmia-associated transcription factor (MITF). Based on linkage analysis of the 31 families, researchers found that their logarithm of odds (LOD) score of 2.7. Other results of the study are also mentioned.