Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates.
Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates.
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大鼠脑干纳米注射阿片类药物的行为和三叉神经元效应。
DOI：
10.1016/0031-9384(92)90434-4
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发表时间：
1992
影响因子：
2.9
通讯作者：
Rosenfeld,JP
中科院分区：
文献类型：
--
作者：
Xia,LY;Huang,KH;Rosenfeld,JP
在副巨细胞核（PGC）和导水管周围灰质（PAG）中单次注射甲硫氨酸脑啡肽（ME；27只大鼠）和人工脑脊液（ACF；9只大鼠），以及同时联合注射PAG + PGC，并研究对面部反应性和尾三叉神经元活动的影响。结果发现，所有 ME 注射都会抑制对有害刺激引起的兴奋性神经元和行为反应。与单次注射效果相比，联合注射具有明显的累加效果。联合注射或单次注射均对自发神经元活动没有系统影响。 ACF 对任何神经元或行为活动没有影响。
Single injections of Met-enkephalin (ME; 27 rats) and artificial cerebrospinal fluid (ACF; 9 rats) in nucleus reticularis paragigantocellularis (PGC) and periaqueductal gray (PAG), and simultaneous conjoint PAG + PGC injections were made, and effects on facial responsiveness and caudal-trigeminal nuclear neuronal activity studied. It was found that all ME injections depressed the evoked excitatory neuronal and behavioral responses to noxious stimulation. Conjoint injections had apparently additive effects in comparison to single injection effects. Neither conjoint nor single injections had systematic effects on spontaneous neuronal activity. The ACF had no effects on any neuronal or behavioral activity.