A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography
A combined time-of-flight and depth-of-interaction detector for total-body positron emission tomography
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DOI：
10.1118/1.4940355
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发表时间：
2016-02-01
期刊：
影响因子：
3.8
通讯作者：
Cherry, Simon R.
中科院分区：
文献类型：
--
作者：
Berg, Eric;Roncali, Emilie;Cherry, Simon R.
目的：在支持一个项目，以建立一个全身PET扫描仪的轴向视场为2米，作者正在开发简单，具有成本效益的块检测器结合飞行时间（TOF）和深度的相互作用（DOI）capabilities.Methods：这项工作的重点是调查潜在的磷涂层晶体与传统的PMT为基础的块检测器读出提供DOI信息，同时保持定时分辨率。作者探索了各种磷光体涂层配置与单晶和晶体阵列。结果：基于延迟电荷积分（DCI）的脉冲形状鉴别技术提供了最低的DOI定位误差，单颗荧光粉涂层晶体的DOI定位误差为2 mm，而块探测器模块的DOI定位误差为3 ~ 3.5 mm。与未涂覆的晶体相比，用单个磷光体涂覆的晶体观察到最小的定时分辨率退化，并且与没有磷光体涂层的404 ps相比，在块检测器中用磷光体涂覆的晶体获得442 ps的定时分辨率。洪水地图显示，与磷光体涂层晶体的晶体分辨率略有下降，但是，所有的晶体可以解决。与未涂覆的晶体相比，涂覆荧光粉的晶体的能量分辨率降低了3%-7%。结论：这些结果证明了使用涂覆荧光粉的晶体通过简单的块检测器读出获得TOF DOI功能的可行性。(C)2016年美国医学物理学家协会。
Purpose: In support of a project to build a total-body PET scanner with an axial field-of-view of 2 m, the authors are developing simple, cost-effective block detectors with combined time-of-flight (TOF) and depth-of-interaction (DOI) capabilities.Methods: This work focuses on investigating the potential of phosphor-coated crystals with conventional PMT-based block detector readout to provide DOI information while preserving timing resolution. The authors explored a variety of phosphor-coating configurations with single crystals and crystal arrays. Several pulse shape discrimination techniques were investigated, including decay time, delayed charge integration (DCI), and average signal shapes.Results: Pulse shape discrimination based on DCI provided the lowest DOI positioning error" 2 mm DOI positioning error was obtained with single phosphor-coated crystals while 3-3 5 mm DOI error was measured with the block detector module. Minimal timing resolution degradation was observed with single phosphor-coated crystals compared to uncoated crystals, and a timing resolution of 442 ps was obtained with phosphor-coated crystals in the block detector compared to 404 ps without phosphor coating. Flood maps showed a slight degradation in crystal resolvability with phosphor-coated crystals; however, all crystals could be resolved. Energy resolution was degraded by 3%-7% with phosphor-coated crystals compared to uncoated crystals.Conclusions: These results demonstrate the feasibility of obtaining TOF DOI capabilities with simple block detector readout using phosphor-coated crystals. (C) 2016 American Association of Physicists in Medicine.