Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses
Flow patterns and wall shear stress distribution in human internal carotid arteries: The geometric effect on the risk for stenoses
复制标题
人体颈内动脉的血流模式和壁剪切应力分布：对狭窄风险的几何效应
DOI：
10.1016/j.jbiomech.2011.10.001
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发表时间：
2012-01-03
影响因子：
2.4
通讯作者：
Li, Deyu
中科院分区：
文献类型：
--
作者：
Zhang, Chi;Xie, Sheng;Li, Deyu
人们广泛观察到动脉粥样硬化性狭窄发生在血流动力学复杂的部位，如高曲率或分叉处的动脉。这些区域通常具有非常低或高度振荡的壁面剪应力(WSS)。本文对不同几何形状的颈内动脉(ICA)模型的三维正弦脉动血流进行了数值模拟。沿颈动脉虹吸管有三个狭窄的好发部位，WSS低振荡和高振荡。用时间平均WSS和振荡剪切指数(OSI)来衡量这些部位狭窄的风险。3种类型颈内动脉狭窄的局部危险性不同，提示血管几何形状在动脉粥样硬化形成中起重要作用。特别是，血管的大曲率和平面度被发现增加了狭窄的风险，因为它们往往会降低WSS和升高OSI。因此，只要测量颈内动脉的形状，几何研究就有可能估计颈内动脉虹吸管的狭窄位置。(C)2011爱思唯尔有限公司。保留所有权利。
It has been widely observed that atherosclerotic stenosis occurs at sites with complex hemodynamics, such as arteries with high curvature or bifurcations. These regions usually have very low or highly oscillatory wall shear stress (WSS). In the present study, 3D sinusoidally pulsatile blood flow through the models of internal carotid artery (ICA) with different geometries was investigated with computational simulation. Three preferred sites of stenoses were found along the carotid siphon with low and highly oscillatory WSS. The risk for stenoses at these sites was scaled with the values of time-averaged WSS and oscillating shear index (OSI). The local risk for stenoses at every preferred site of stenoses was found different between 3 types of ICA, indicating that the geometry of the blood vessel plays significant roles in the atherogenesis. Specifically, the large curvature and planarity of the vessel were found to increase the risk for stenoses, because they tend to lower WSS and elevate OSI. Therefore, the geometric study makes it possible to estimate the stenosis location in the ICA siphon as long as the shape of ICA was measured. (C) 2011 Elsevier Ltd. All rights reserved.