Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats
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DOI：
10.1093/ecam/nen001
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发表时间：
2010-09-01
影响因子：
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通讯作者：
Singh, Raj Kumar
中科院分区：
文献类型：
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作者：
Kumar, Vishnu;Khan, Mohammad Mubin;Singh, Raj Kumar
在triton WR-1339诱导的大鼠高脂血症中研究了印度花（茜草科;印度语名称Kadamba）根提取物的降脂活性。在该模型中，用根提取物（500 mg kg（-1）b.w.）降低高血脂大鼠的血脂并重新激活肝素后的脂解活性。此外，根提取物（50-500 μ M）在体外酶促和非酶促系统中抑制超氧阴离子和羟基自由基的产生。本研究结果表明，芦荟根提取物具有降血脂和抗氧化活性。结论：薏苡仁提取物具有预防高脂血症及相关疾病的作用。
The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg(-1) b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50-500 mu M) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.