Genetic control of Adh expression in Drosophila melanogaster.
Genetic control of Adh expression in Drosophila melanogaster.
复制标题
果蝇中 Adh 表达的遗传控制。
作者：
G. Maroni;C. C. Laurie
显示不同水平的乙醇脱氢酶（Adh）基因表达的天然变体进行遗传作图实验。所研究的菌株携带两种常见的酶电泳形式之一。耐Adh菌株之间的差异似乎是由于多个位点的反式作用的影响。Adh慢毒株之间的差异是由于修饰物或定量位点非常接近结构基因（小于0.05图单位）或其一部分。在Adhs毒株中检测到的修饰物似乎只对顺式位置的结构等位基因起作用。在Adhs菌株中还检测到影响幼虫和成虫中ADH水平比率的修饰剂。这种修饰剂也与Adh紧密相连，并且是顺式作用的。
Natural variants displaying different levels of expression of the gene for alcohol dehydrogenase (Adh) were subjected to genetic mapping experiments. The strains studied carry one of the two common electrophoretic forms of the enzyme. The difference among Adh-fast strains appears to be due to multiple loci with trans-acting effects. Differences among Adh-slow strains are due to modifiers or quantitative sites located very close to the structural gene (less than 0.05 map unit) or part of it. The modifiers detected in the Adhs strains seem to operate only on the structural allele in the cis-position.--A modifier that affects the ratio of ADH levels in larvae and adults was also detected in the Adhs strains. This modifier is also closely linked to Adh and is cis-acting.