5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum
5-lipoxygenase expression in a brain damage model induced by chronic oral administration of aluminum
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DOI：
10.3969/j.issn.1673-5374.2010.21.006
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发表时间：
2010-11-15
影响因子：
6.1
通讯作者：
Su, Qiang
中科院分区：
文献类型：
--
作者：
Pan, Yongquan;Zhang, Peng;Su, Qiang
初步研究发现，5-脂氧合酶抑制剂咖啡酸对脑室微量注射铝所致的急性脑损伤有明显的保护作用。本实验采用大鼠慢性灌胃铝建立慢性脑损伤和神经元变性模型，并用咖啡酸进行干预。结果表明，咖啡酸可下调慢性铝超负荷诱导的5-脂氧合酶基因和蛋白的表达，修复铝超负荷所致的海马神经元损伤和空间定向性损伤。提示直接干预5-脂氧合酶表达对慢性铝超负荷脑损伤模型变性具有神经保护作用。
A preliminary study has found that the 5-lipoxygenase inhibitor, caffeic acid, has a marked protective effect on acute brain injury induced by intracerebroventricular microinjection of aluminum. In this experiment, chronic brain injury and neuronal degeneration model was established in rats by chronic oral administration of aluminum, and then intervened using caffeic acid. Results showed that caffeic acid can downregulate chronic aluminum overload-induced 5-lipoxygenase mRNA and protein expression, and repair the aluminum overload-induced hippocampal neuronal damage and spatial orientation impairment. It is suggested that direct intervention of 5-lipoxygenase expression has a neuroprotective role in the degeneration induced by chronic aluminum overload brain injury model.