In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities.
In vivo measurements of glucose uptake in human Achilles tendon during different exercise intensities.
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DOI：
10.1055/s-2005-837458
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发表时间：
2005-11
影响因子：
2.5
通讯作者：
J. Hannukainen;K. Kalliokoski;P. Nuutila;T. Fujimoto;J. Kemppainen;T. Viljanen;M. Laaksonen;R. Parkkola;J. Knuuti;M. Kjaer
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文献类型：
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作者：
J. Hannukainen;K. Kalliokoski;P. Nuutila;T. Fujimoto;J. Kemppainen;T. Viljanen;M. Laaksonen;R. Parkkola;J. Knuuti;M. Kjaer
肌肉收缩和相邻肌腱的负荷已被证明会导致腹膜周围区域的血流量和代谢活动增加。然而，在运动过程中，人体肌腱本身吸收葡萄糖的程度尚不清楚。因此，本研究的目的是测量随运动强度增加而增加的肌腱葡萄糖摄取，并将其与相同强度下的肌肉葡萄糖摄取进行比较。研究人员对8名年轻男性进行了为期三天的测试，在此期间，他们分别以30%、55%和75%的最大摄氧量进行了35分钟的骑行。葡萄糖摄取直接通过正电子发射断层扫描（PET）用2-[(18)F]氟-2-脱氧葡萄糖（[18F]FDG）测量。[18F]运动10分钟后注射FDG，注射后继续注射25分钟。运动后对大腿和跟腱区域进行PET扫描。跟腱的葡萄糖摄取（AT）保持不变（7.1 +/- 1.5、6.6 +/- 1.1和6.0 +/- 1.1微摩尔。kg(-1)）。Min(-1))随着工作量的增加而增加，尽管股四头肌的葡萄糖摄取同时明显增加(48 +/- 35、120 +/- 35和152 +/- 74微摩尔。kg（-1）。Min (-1), p < 0.05)。总之，在运动过程中，AT会吸收葡萄糖，但比骨骼肌吸收的葡萄糖要少得多。此外，AT中的葡萄糖摄取并不随着运动强度的增加而增加。这可以部分解释为本研究中使用的循环几何运动，随着运动强度的增加，可能只会导致AT的应变增加很少。
Muscular contraction and loading of adjacent tendons has been demonstrated to cause increased blood flow and metabolic activity in the peritendinous region. However, it is poorly known to what extent the human tendon itself takes up glucose during exercise. Thus, the purpose of this study was to measure tendon glucose uptake with increasing exercise intensity and to compare it to muscle glucose uptake at the same intensities. Eight young men were examined on three separate days during which they performed 35 min of cycling at 30, 55 and 75 % of VO2max, respectively. Glucose uptake was measured directly by positron emission tomography (PET) with 2-[ (18)F]fluoro-2-deoxyglucose ([18F]FDG). [18F]FDG was injected after 10 min of exercise that was continued for a further 25 min after the injection. PET scanning of the thigh and Achilles region was performed after the exercise. Glucose uptake of the Achilles tendon (AT) remained unchanged (7.1 +/- 1.5, 6.6 +/- 1.1, and 6.0 +/- 1.1 micromol.kg(-1).min(-1)) with the increasing workload, although the glucose uptake in m. quadriceps femoris simultaneously clearly increased (48 +/- 35, 120 +/- 35, and 152 +/- 74 micromol.kg(-1).min(-1), p < 0.05). In conclusion, the AT takes up glucose during exercise but in significantly smaller amounts than the skeletal muscle does. Furthermore, glucose uptake in the AT is not increased with the increasing exercise intensity. This may be partly explained by the cycle ergometry exercise used in the present study, which probably causes only a little increase in strain to the AT with increasing exercise intensity.