Mucosal mast cells and the allergic response against nematode parasites
Mucosal mast cells and the allergic response against nematode parasites
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DOI：
10.1016/s0165-2427(96)05696-6
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发表时间：
1996-11-01
影响因子：
1.8
通讯作者：
Miller, HRP
中科院分区：
文献类型：
--
作者：
Miller, HRP
在线虫感染的粘膜表面，IgE介导的I型过敏反应被认为具有直接的保护功能。粘膜肥大细胞（MMC）的贡献，这些粘膜过敏反应的审查。在线虫感染期间，除了辅助性T细胞2介导的MMC增生调节外，试剂盒配体干细胞因子（SCF）在MMC反应的早期发展中起关键作用。在小鼠中的研究表明，MMC可防止某些进入粘膜的线虫，但不能防止管腔寄生线虫。MMC在其他物种（包括绵羊）中的保护作用不太确定，并且有一些证据表明MMC可能增强寄生虫繁殖力。测量全身释放并进入肠腔的MMC特异性颗粒糜酶，可以精确监测肥大细胞活化，并表明分泌的糜酶可能靶向上皮连接复合物蛋白，从而导致粘膜通透性增加。因此，在寄生粘膜中发现的丰富的上皮内MMC可以作为上皮守门人，允许血浆蛋白易位到粘膜表面上。
IgE-mediated Type-I allergic reactions at nematode-infected mucosal surfaces are considered to have a direct protective function. The contribution of mucosal mast cells (MMC) to these mucosal allergic responses is reviewed. In addition to the T helper 2 cell-mediated regulation of MMC hyperplasia during nematode infection the kit ligand, stem cell factor (SCF), plays a key role in the early development of the MMC response. Studies in the mouse suggest that MMC protect against certain nematodes which enter the mucosa but not against lumen dwelling nematodes. The protective roles of MMC in other species, including sheep, are less certain and there is some evidence that MMC might enhance parasite fecundity, The measurement of MMC-specific granule chymases released systemically, and into the gut lumen, permits precise monitoring of mast cell activation and suggests that the secreted chymases may target epithelial junctional complex proteins, thereby causing increased mucosal permeability. The abundant intraepithelial MMC found in parasitised mucosa may, therefore, serve as epithelial gatekeepers permitting the translocation of plasma proteins onto the mucosal surface.