Determination of Abraham model solute descriptors for o-acetoacetanisidide based on experimental solubility data in organic mono-solvents
Determination of Abraham model solute descriptors for o-acetoacetanisidide based on experimental solubility data in organic mono-solvents
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DOI：
10.1080/00319104.2018.1496438
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发表时间：
2019-07-04
影响因子：
1.2
通讯作者：
Abraham, Michael H.
中科院分区：
文献类型：
--
作者：
Lee, Grace;Che, Melanie;Abraham, Michael H.
用分光光度法测定了邻乙酰乙氨基苯甲醚在13种醇类溶剂中的溶解度（乙醇、1-丙醇、1-丁醇、1-戊醇、1-己醇、1-庚醇、2-丙醇、2-丁醇、2-甲基-1-丙醇、2-甲基-2-丙醇、2-甲基-2-丁醇、3-甲基-1-丁醇和4-甲基-2-戊醇），在3种二烷基醚溶剂（二异丙醚、丁二醚和甲基叔丁基醚）、6种烷酸烷基酯溶剂（乙酸甲酯、乙酸乙酯、乙酸丙酯、乙酸丁酯、乙酸戊酯和丁酸甲酯）和1种烷腈溶剂（丙腈）中，在298.15 K下，溶质描述符计算o-乙酰乙酰茴香胺根据亚伯拉罕溶剂化参数模型通过分析测得的溶解度数据。计算的溶质描述符描述了观察到的溶解度数据，在0.099对数单位内。
Spectrophotometric methods were used to measure the mole fraction solubility of o-acetoacetanisidide dissolved in 13 alcohol solvents (ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, 1-heptanol, 2-propanol, 2-butanol, 2-methyl-1-propanol, 2-methyl-2-propanol, 2-methyl-2-butanol, 3-methyl-1-butanol and 4-methyl-2-pentanol), in 3 dialkyl ether solvents (diisopropyl ether, dibutyl ether and methyl tert-butyl ether), in 6 alkyl alkanoate solvents (methyl acetate, ethyl acetate, propyl acetate, butyl acetate, pentyl acetate and methyl butyrate) and in 1 alkanenitrile solvent (propanenitrile) at 298.15 K. Solute descriptors were calculated for o-acetoacetanisidide by analysing the measured solubility data in accordance with the Abraham solvation parameter model. The calculated solute descriptors describe the observed solubility data to within 0.099 log units.