Na+C/H+ exchangers:: Structure, function and regulation
Na+C/H+ exchangers:: Structure, function and regulation
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DOI：
10.1358/dnp.1999.12.2.863626
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发表时间：
1999-03-01
影响因子：
--
通讯作者：
Grinstein, S
中科院分区：
文献类型：
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作者：
Aharonovitz, O;Grinstein, S
近年来，我们对Na+/H+交换(NHE)家族成员的结构和功能调控的了解有了显着的进步。到目前为止，已鉴定出6种哺乳动物NHE亚型(NHE1-NHE6)。根据它们的水化剖面，所有的NHEs都呈现出相似的拓扑结构。NHE1在几乎所有的组织和细胞中都有表达，但NHE2、NHE3、NHE4和NHE5的分布比NHE1更有限。虽然NHE6在线粒体丰富的组织中含量最高，但它在所有组织中都有表达。NHE异构体最容易通过它们的药理学特性来区分，更具体地说，通过它们对阿米洛利及其类似物的敏感性。Na+/H+交换的调节受到氯离子、囊泡运输和膜相关脂类，特别是磷脂的影响；然而，这些不同因素中的每一个所起的作用还需要进一步阐明，(C)1999《科学》杂志。版权所有。
Our knowledge of the structure and functional regulation of members of the Na+/H+ exchanger (NHE) family has advanced notably in recent years. To date, six mammalian NHE isoforms (NHE1-NHE6) have been identified. On the basis of their hydropathy profiles, all NHEs exhibit similar topologies. NHE1 is expressed in virtually all tissues and cells, but the distributions of NHE2, NHE3, NHE4 and NHE5 are more restricted than that of NHE1. NHE6 is ubiquitously expressed, although it is most abundant in mitochondria-rich tissues. NHE isoforms are most easily distinguished by their pharmacological properties, more specifically, by their sensitivity to amiloride and its analogs. The regulation of Na+/H+ exchange is influenced by Cl-, vesicular traffic and membrane-associated lipids, particularly phospholipids; however, the roles played by each of these different factors require further elucidation, (C) 1999 Prous Science. All rights reserved.