Peroxisome proliferation associated with fibrinogen storage in the liver

Peroxisome proliferation associated with fibrinogen storage in the liver
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过氧化物酶体增殖与肝脏中纤维蛋白原储存相关

DOI：
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发表时间：
1996
期刊：
Histopathology
影响因子：
6.4
通讯作者：
C. van den Branden
C. van den Branden
中科院分区：
医学2区
文献类型：
--
作者：
D. de Craemer;M. Pipeleers‐Marichal;Y. Vandenplas;C. van den Branden

文献摘要

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我们报告了一名患有纤维蛋白原贮积病的患者，其肝细胞中正常大小的过氧化物酶体增殖。这种现象之前已在几种获得性肝病中被描述过。我们认为，这是由于内质网中纤维蛋白原过量积累导致微粒体同工酶活性降低而产生的适应反应。
We report a patient with fibrinogen storage disease in which there was proliferation of normal‐sized peroxisomes in the hepatocytes. This phenomenon has previously been described in several acquired liver diseases. We believe that this is an adaptation response due to decreased microsomal isoenzyme activity as a result of the excess accumulation of fibrinogen in the endoplasmic reticulum.