Effects of dietary selenium species on Se concentrations in hair, blood, and urine.
Effects of dietary selenium species on Se concentrations in hair, blood, and urine.
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膳食硒种类对头发、血液和尿液中硒浓度的影响。
DOI：
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发表时间：
1998
影响因子：
3.8
通讯作者：
K. Suzuki
中科院分区：
文献类型：
--
作者：
Y. Shiobara;T. Yoshida;K. Suzuki
研究了饲粮中硒的化学种类和浓度对毛发、血清、红细胞和尿液中硒浓度的影响，以了解不同化学形式硒的毒理学和营养意义。雄性Wistar大鼠先饲喂缺硒（硒≤0.03微克/克）饲粮3周，然后再饲喂含硒l -蛋氨酸（SeMet）或亚硒酸盐的足硒（硒≤0.2微克/克）或过量硒（硒≤2.0微克/克）饲粮12周。每两周采集一次毛发、血液和尿液标本，测定血清和尿液中的硒浓度及其在粒径排除柱上的分布。在饲粮硒浓度发生变化后2周，毛发、血清和尿液中的硒浓度达到恒定水平，而与化学物质无关，其水平取决于化学物质和浓度。具体而言，在头发和血清中，无论剂量如何，亚硒酸盐的恒定水平最低，而SeMet的水平以剂量依赖的方式高于亚硒酸盐。血清中两种主要硒蛋白的浓度相当。另一方面，尿中硒的浓度与剂量有关，而与化学物质无关。这一结果可以解释为亚硒酸盐代谢的调控，以及亚硒酸盐代谢的非调控和调控两个方面。
The effects of the chemical species and concentration of selenium (Se) in diets on the concentrations of Se in hair, blood serum, red blood cells (RBCs), and urine were studied to gain an insight into the toxicological and nutritional significance of different chemical forms of Se. Male Wistar rats were fed an Se-deficient diet (Se, less than 0.03 microgram/g) for 3 weeks, and then an Se-adequate (Se, 0.2 microgram/g) or Se-excess diet (Se, 2.0 micrograms/g), including seleno-L-methionine (SeMet) or selenite for up to 12 weeks. Hair, blood, and urine specimens were obtained every two weeks, and the concentrations of Se and its distribution in serum and urine on a size-exclusion column were determined. The concentrations of Se in hair, serum, and urine attained constant levels 2 weeks after a change of in the dietary Se concentration irrespective of the chemical species, the levels being dependent on the chemical species and the concentration. Specifically, in hair and serum, selenite gave the lowest constant levels irrespective of the dose, while SeMet resulted in higher levels than selenite in a dose-dependent manner. The two major selenoproteins in serum exhibited comparable concentrations. On the other hand, in urine, the concentration of Se was dependent on the dose but not on the chemical species. The results could be explained by regulated metabolism of selenite, and both nonregulated and regulated aspects of the metabolism of SeMet.
影响因子：
4.5
作者：
G. W. Martin;J. Harney;M. Berry
通讯作者：
G. W. Martin;J. Harney;M. Berry
DOI：
10.1073/pnas.90.2.537
发表时间：
1993-01-15
影响因子：
11.1
作者：
HILL, KE;LLOYD, RS;BURK, RF
通讯作者：
BURK, RF