highlighted topics Physiological and Genomic Consequences of Intermittent Hypoxia Invited Review: Intermittent hypoxia and respiratory plasticity
highlighted topics Physiological and Genomic Consequences of Intermittent Hypoxia Invited Review: Intermittent hypoxia and respiratory plasticity
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综述：间歇性缺氧与呼吸可塑性。J Appl Physiol 90：2466-2475，2001.-间歇性低氧诱发长时程易化（LTF），即呼吸运动输出的持续增强（小时）。最近已经取得了相当大的进展，对这一潜在的重要模型的呼吸可塑性的机制和表现的理解。LTF由间歇性而非持续性缺氧引起，表明其潜在机制中存在前发现模式敏感性。在间歇性缺氧期间，脊髓5-羟色胺受体的间歇性激活启动细胞信号传导事件，增加脊髓蛋白质合成。一种相关的蛋白质是脑源性神经营养因子，一种与几种形式的突触可塑性有关的神经营养因子。我们的工作假设是，增加脑源性神经营养因子增强膈运动神经元的突触能电流，增加其对球脊髓吸气输入的反应。LTF在呼吸输出中是异质的，在实验制剂中是不同的，并且受年龄、性别和遗传的影响。此外，LTF在慢性间歇性缺氧后增强，表明一定程度的可塑性。虽然LTF的生理相关性尚不清楚，但它可能反映了一种一般机制，即间歇性5-羟色胺
Review: Intermittent hypoxia and respiratory plasticity. J Appl Physiol 90: 2466–2475, 2001.— Intermittent hypoxia elicits long-term facilitation (LTF), a persistent aug- mentation (hours) of respiratory motor output. Considerable recent progress has been made toward an understanding of the mechanisms and manifestations of this potentially important model of respiratory plasticity. LTF is elicited by intermittent but not sustained hypoxia, indicating pro- found pattern sensitivity in its underlying mechanism. During intermittent hypoxia, episodic spinal serotonin receptor activation initiates cell signaling events, increasing spinal protein synthesis. One associated protein is brain-derived neurotrophic factor, a neurotrophin implicated in several forms of synaptic plasticity. Our working hypothesis is that increased brain-derived neurotrophic factor enhances glutamatergic synaptic currents in phrenic motoneurons, increasing their responsiveness to bulbospinal inspiratory inputs. LTF is heterogeneous among respiratory outputs, differs among experimental preparations, and is influenced by age, gender, and genetics. Furthermore, LTF is enhanced following chronic intermittent hypoxia, indicating a degree of metaplasticity. Although the physiological relevance of LTF remains unclear, it may reflect a general mechanism whereby intermittent serotonin