Enantioselective Synthesis of Macrocyclic Heterobiaryl Derivatives by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis Inducing Winding Vine-Shaped Molecular Asymmetry
Enantioselective Synthesis of Macrocyclic Heterobiaryl Derivatives by Molybdenum-Catalyzed Asymmetric Ring-Closing Metathesis Inducing Winding Vine-Shaped Molecular Asymmetry
复制标题
钼催化不对称闭环易位诱导缠绕藤形分子不对称对映选择性合成大环杂联芳衍生物
DOI：
10.1002/anie.201500459
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
M. Ogasawara
中科院分区：
文献类型：
--
作者：
Y. Okayama;S. Tsuji;Y. Toyomori;T. Mori;S. Arae;W.-Y. Wu;T. Takahashi;M. Ogasawara
通过使用手性钼催化剂的对映选择性闭环复分解反应诱导缠绕藤状分子不对称性。该反应在温和条件下进行，通过E-选择性闭环复分解，产生对映选择性高达96%ee的大环双唑。
Winding vine‐shaped molecular asymmetry is induced by enantioselective ring‐closing metathesis with a chiral molybdenum catalyst. The reaction proceeds under mild conditions through anE‐selective ring‐closing metathesis leading to macrocyclic bisazoles with enantioselectivities of up to 96 %ee.