Depression and reduced sensitivity to non-rewards versus rewards: Evidence from event-related potentials
Depression and reduced sensitivity to non-rewards versus rewards: Evidence from event-related potentials
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DOI：
10.1016/j.biopsycho.2008.12.004
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发表时间：
2009-04-01
影响因子：
2.6
通讯作者：
Hajcak, Greg
中科院分区：
文献类型：
--
作者：
Foti, Dan;Hajcak, Greg
近年来，抑郁症的特征在于积极情感的缺陷和与积极态度相关的动机系统。与这一观点相一致的是，行为和皮层电研究表明，对奖励的敏感性降低可能是抑郁症的一个基本特征。在事件相关电位文献中，反馈负性（FN）已被确定为对非奖励与奖励反馈敏感的成分，并与中脑多巴胺水平的阶段性变化有关，这些变化表明事件是否比预期更好或更差;因此，FN可能是与抑郁症相关的奖励敏感性异常的有用标志物。在目前的研究中，一个简单的赌博任务被用来引起参与者的FN，FN的大小与抑郁症状的水平，以及焦虑和压力的水平有关。增强的FN非奖励相对于奖励被认为是负相关的抑郁症和压力反应，只有FN和压力之间的关系仍然显着控制后的其他心理变量。与此同时，反馈的P3与抑郁和焦虑评分呈负相关，无论反馈类型如何。这些结果进行了讨论的背景下，目前的抑郁症和奖励的敏感性模型。(C)2008 Elsevier B. V.保留所有权利。
Depression has been characterized in recent years in terms of deficits in positive affect and an underactive approach-related motivational system. Consistent with this view, behavioral and electrocortical studies suggest that reduced sensitivity to rewards may be a fundamental feature of depression. Within the event-related potential literature, the feedback negativity (FN) has been identified as a component that is sensitive to feedback indicating non-rewards versus rewards, and has been linked to phasic changes in midbrain dopamine levels that indicate whether events are better or worse than expected; thus, the FN may be a useful marker for abnormalities in reward sensitivity associated with depression. In the current study, a simple gambling task was used to elicit an FN in participants, and the magnitude of the FN was related to levels of depressive symptoms, as well as levels of anxiety and stress. The enhancement of the FN to non-rewards relative to rewards was found to be inversely related to depression and stress reactivity; only the relationship between the FN and stress remained significant after controlling for the other psychological variables. The P3 to feedback, meanwhile, was inversely related to depression and anxiety scores regardless of feedback type. These results are discussed within the context of current models of depression and reward sensitivity. (C) 2008 Elsevier B.V. All rights reserved.