Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase
Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase
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DOI：
10.1210/jc.2004-2033
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发表时间：
2005-04-01
影响因子：
5.8
通讯作者：
Richardson, GS
中科院分区：
文献类型：
--
作者：
Hall, JE;Sullivan, JP;Richardson, GS
为了确定睡眠、睡眠阶段和一天中的时间对月经周期早期卵泡期（EFP）脉冲式LH分泌动力学的影响，11名正常妇女在40- 60岁期间进行了频繁抽样研究，同时进行多导睡眠监测和LH测量。h方案，包括一个晚上的正常睡眠和一个晚上的睡眠剥夺，然后午睡。LH脉冲间期在睡眠时比清醒时长，无论是否发生在夜间或白天（P < 0.002），这意味着减少GnRH脉冲频率与睡眠的EFP。LH脉冲幅度在睡眠时比清醒时大（P < 0.001），且较大的脉冲幅度与睡眠时较长的脉冲间期相关（P < 0.005），但与清醒时无关。平均LH在睡眠和白天时间之间存在相互作用，睡眠时的平均LH水平低于夜间清醒时的水平（P < 0.02），但在白天则不然。与I/II、III/IV期（慢波）或快速眼动睡眠相比，觉醒更可能与LH脉冲相关（P < 0.005）。此外，在LH脉冲开始前5 - 15分钟，睡眠期内觉醒的可能性增加（相对于随机选择的非脉冲LH; P < 0.05），提示觉醒是主要事件。在无睡眠的情况下，一天中的时间对平均LH有影响LH脉冲幅度（P <0.03），最大值出现在晚上。总之，在EFP中，LH脉冲频率的抑制与睡眠有关，而不是一天中的时间。在睡眠期间，LH脉冲最常与短暂的觉醒相关，这表明睡眠中断可以逃避睡眠对GnRH脉冲分泌的抑制作用。在无睡眠的情况下，还观察到一天中的时间对LH脉冲动力学的单独影响，LH脉冲幅度和平均水平在夜间增加;然而，需要进行额外的研究以确定这是否代表真正的昼夜节律效应。
To determine the influence of sleep, sleep stage, and time of day on the dynamics of pulsatile LH secretion in the early follicular phase (EFP) of the menstrual cycle, 11 normal women underwent simultaneous polysomnographic monitoring of sleep and measurement of LH in frequent sampling studies during a 40-h protocol that consisted of one night of normal sleep and one night of sleep deprivation followed by an afternoon nap.The interpulse interval of LH was longer during sleep than wake whether it occurred at night or during the day ( P < 0.002), implying a decrease in GnRH pulse frequency associated with sleep in the EFP. LH pulse amplitude was greater during sleep than wake ( P < 0.001) and greater pulse amplitudes were associated with longer interpulse intervals during sleep ( P < 0.005), but not wake. An interaction between sleep and time of day was observed for mean LH, with lower mean LH levels during sleep than wake at night ( P < 0.02), but not during the day.Wakefulness was more likely to be associated with an LH pulse than were stages I/II, III/IV ( slow wave), or rapid eye movement sleep ( P < 0.005). In addition, the probability of wakefulness within the sleep episode increased 5 - 15 min before the onset of LH pulses ( relative to randomly selected nonpulse LH; P < 0.05), suggesting that wakefulness was the primary event.In the absence of sleep, there was an effect of time of day on mean LH ( P < 0.02) and LH pulse amplitude ( P < 0.03), with greatest values seen during the evening. In conclusion, in the EFP, inhibition of LH pulse frequency is related to sleep rather than time of day. During periods of sleep, LH pulses occur most commonly in association with brief awakenings, suggesting that interruptions from sleep allow escape from the inhibitory effect of sleep on pulsatile GnRH secretion. A separate effect of time of day on LH pulse dynamics in the absence of sleep was also observed with evening augmentation of LH pulse amplitude and mean level; however, additional studies will be required to determine whether this represents a true circadian effect.