The Insertion/Deletion Polymorphism of Angiotensin I Converting Enzyme Gene is Associated With Ossification of the Posterior Longitudinal Ligament in the Korean Population.
The Insertion/Deletion Polymorphism of Angiotensin I Converting Enzyme Gene is Associated With Ossification of the Posterior Longitudinal Ligament in the Korean Population.
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DOI：
10.5535/arm.2014.38.1.1
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发表时间：
2014-02
期刊：
影响因子：
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通讯作者：
Lee SY
中科院分区：
文献类型：
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作者：
Kim DH;Yun DH;Kim HS;Min SK;Yoo SD;Lee KH;Kim KT;Jo DJ;Kim SK;Chung JH;Ban JY;Lee SY
确定韩国人群中ACE插入/缺失（I/D）多态性是否与脊柱后纵韧带骨化（OPLL）相关。通过病例对照研究血管紧张素I转换酶（肽二肽酶A） 1 （ACE）基因I/D多态性与OPLL的关系。选取OPLL患者95例，对照组274例。应用聚合酶链反应对ACE I/D多态性进行基因分型。采用χ2检验和logistic回归分析比较OPLL患者与对照组的差异。统计分析采用SPSS、SNPStats、SNPAnalyzer、Helixtree等软件。ACE I/D多态性基因型和等位基因频率在OPLL患者与对照组之间存在显著差异（基因型，p<0.001；等位基因，p=0.009）。OPLL组的D/D基因型和D等位基因频率均高于对照组。logistic回归分析显示，ACE I/D多态性与OPLL相关（优势模型；p=0.002；奇比2.20；95%置信区间1.33-3.65）。这些结果提示ACE基因的缺失多态性可能是韩国人群发生OPLL的危险因素。
To determine whether ACE insertion/deletion (I/D) polymorphism is associated with the ossification of the posterior longitudinal ligament (OPLL) of the spine in the Korean population. A case-control study was conducted to investigate the association between I/D polymorphism of the angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE) gene and OPLL. The 95 OPLL patients and 274 control subjects were recruited. Polymerase chain reaction for the genotyping of ACE I/D polymorphism was performed. The difference between the OPLL patients and the control subjects was compared using the contingency χ2 test and the logistic regression analysis. For statistical analysis, SPSS, SNPStats, SNPAnalyzer, and Helixtree programs were used. The genotype and allele frequencies of ACE I/D polymorphism showed significant differences between the OPLL patients and the control subjects (genotype, p<0.001; allele, p=0.009). The frequencies of D/D genotype and D allele in the OPLL group were higher than those in the control group. In logistic regression analysis, ACE I/D polymorphism was associated with OPLL (dominant model; p=0.002; odd ratio, 2.20; 95% confidence interval, 1.33-3.65). These results suggest that the deletion polymorphism of the ACE gene may be a risk factor for the development of OPLL in the Korean population.