The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.
The role of nuclear Y-box binding protein 1 as a global marker in drug resistance.
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DOI：
10.1158/1535-7163.1485.3.11
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发表时间：
2004-11
影响因子：
5.7
通讯作者：
M. Kuwano;Y. Oda;H. Izumi;Song‐Ju Yang;T. Uchiumi;Y. Iwamoto;M. Toi;T. Fujii;H. Yamana;H. Kinoshita;T. Kamura;M. Tsuneyoshi;K. Yasumoto;K. Kohno
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文献类型：
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作者：
M. Kuwano;Y. Oda;H. Izumi;Song‐Ju Yang;T. Uchiumi;Y. Iwamoto;M. Toi;T. Fujii;H. Yamana;H. Kinoshita;T. Kamura;M. Tsuneyoshi;K. Yasumoto;K. Kohno
基因表达可在转录水平上受核因子调控。许多这样的因子调节MDR 1基因的表达，但是控制该基因的基础表达和诱导表达的序列元件和转录因子是什么？转录因子参与耐药性的一般原理现在开始被理解。在这里，我们回顾了参与MDR 1基因转录调控的因素。特别是，我们专注于转录因子Y-box结合蛋白1和讨论之间的可能联系Y-box结合蛋白1的表达和耐药的癌症，这是介导的跨膜P-糖蛋白或非P-糖蛋白。
Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non-P-glycoprotein.