A phantom study evaluating the quantitative aspect of 3D PET imaging of the brain.
A phantom study evaluating the quantitative aspect of 3D PET imaging of the brain.
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一项评估大脑 3D PET 成像定量方面的模型研究。
DOI：
10.1088/0031-9155/43/9/013
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发表时间：
1998
影响因子：
3.5
通讯作者：
Ruth,TJ
中科院分区：
文献类型：
--
作者：
Sossi,V;Oakes,TR;Ruth,TJ
体模研究用于开发一种可靠的定量数据处理协议，用于FDG和神经受体脑成像中通常遇到的条件下的3D PET脑扫描。这些协议通常跨越注射的放射性示踪剂的几个半衰期，因此导致在研究持续时间内所获取的数据的统计内容变化很大。探测器归一化，散射校正和它们的相互作用在广泛的统计内容的采集数据进行了评价。对数据应用所有其他定量校正后，确定总体灵敏度校准因子。其结果是一个最佳的数据处理协议，其中包括迭代卷积减法散射校正方法，考虑到扫描仪的几何特性和感兴趣的区域的校准程序的归一化程序，按此顺序应用。该方案产生的3D PET定量准确度在扫描条件下独立测量浓度值的约3%范围内，包括采集计数数量从一百万到数亿的变化以及尺寸和形状从20 cm直径体模到最小横截面为的锥形体模的变化。该性能与2D采集模式的性能相当。
Phantom studies are used to develop a reliable quantitative data processing protocol for 3D PET brain scanning for conditions typically encountered in FDG and neuroreceptor brain imaging. These protocols often span several half-lives of the injected radiotracer thus resulting in a greatly varying statistical content of the acquired data over the study duration. Detector normalization, scatter correction and their interplay over a wide range of statistical content of acquired data were evaluated. Overall sensitivity calibration factors were determined after all other quantification corrections were applied to the data. The result is an optimum data processing protocol that includes an iterative convolution subtraction scatter correction method, a normalization procedure that takes into account the geometric properties of the scanner and a region of interest based calibration procedure, applied in this order. This protocol yields a 3D PET quantification accuracy within approximately 3% of independently measured concentration values for scanning conditions that include variation in the number of acquired counts from one million to several hundred millions and variation in size and shape from a 20 cm diameter phantom to a tapered phantom with minimum cross section of. This performance is comparable with that of the 2D acquisition mode.