SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury
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DOI：
10.1172/jci12939
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发表时间：
2001-05-01
影响因子：
15.9
通讯作者：
Sage, EH
中科院分区：
文献类型：
--
作者：
Bradshaw, AD;Sage, EH
SPARC蛋白的结构。由晶体学数据导出的带状图显示了SPARC的三个模畴。每个结构域的代表性活性显示在指定的氨基酸下面。卵泡抑素样结构域包含绿色表示的肽2.1（见参考文献1）和黑色表示的(K) GHK血管生成肽（氨基酸114-130）。EC结构域包含氨基酸255-274（肽4.2），显示为黄色。修改自Hohenester et al.（29）和Brookhaven Protein Database，登录号：1BM0来自参考文献1，已获得许可。
Structure of SPARC protein. A ribbon diagram derived from crystallographic data shows the three modular domains of SPARC. Representative activities attributed to each domain are shown beneath the designated amino acids. The follistatin-like domain contains the peptide 2.1 (see ref. 1) shown in green and the (K) GHK angiogenic peptide (amino acids 114–130) shown in black. The EC domain contains the amino acids 255–274 (peptide 4.2) shown in yellow. Modified from Hohenester et al.(29) and the Brookhaven Protein Database, accession no. 1BM0 from Ref. 1, with permission.