Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies.
Long-term efficacy of donepezil for relapse of visual hallucinations in patients with dementia with Lewy bodies.
复制标题
多奈哌齐对路易体痴呆患者幻视复发的长期疗效。
DOI：
10.1111/psyg.12089
复制
发表时间：
2015
期刊：
影响因子：
2
通讯作者：
Ozaki N.
中科院分区：
文献类型：
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作者：
Ukai K;Fujishiro H;Iritani S;Ozaki N.
研究背景路易体痴呆（DLB）联合会（DLB Consortium）的指南推荐使用胆碱酯酶抑制剂治疗DLB。然而，关于DLB相关幻视的治疗方法尚未达成共识。据我们所知，一个适当的剂量的多奈哌齐治疗DLB在每个阶段还没有discussed.MethodsEight患者患有DLB幻视与多奈哌齐治疗。我们总结了多奈哌齐对这些幻视的影响，按时间顺序在所有情况下，并讨论其疗效和features.ResultsDonepezil有助于在所有情况下的幻视完全消失，其效果维持6个月以上。然而，在所有病例中也发生了幻视复发。对这些复发，增加剂量的多奈哌齐是非常有效的解决他们再次在几乎所有的情况下，在这项study.ConclusionsDonepezil是非常有效的对DLB患者的幻视，但有一些关于药物治疗DLB的问题。
BackgroundThe use of cholinesterase inhibitors is recommended for the treatment of dementia with Lewy bodies (DLB) in the guidelines of the DLB Consortium. However, no consensus regarding therapeutic approaches for DLB‐related visual hallucinations has been reached. To the best of our knowledge, an appropriate dose of donepezil for the treatment of DLB at each stage has not been discussed.MethodsEight patients suffering from DLB with visual hallucinations were treated with donepezil. We summarize the effects of donepezil on these visual hallucinations chronologically in all cases and discuss its efficacy and characteristics.ResultsDonepezil contributed to the complete disappearance of visual hallucinations in all cases, and its effects were maintained for more than 6 months. However, relapses of visual hallucinations also occurred in all cases. Against these relapses, an increased dose of donepezil was very effective in resolving them again in almost all cases in this study.ConclusionsDonepezil was highly effective against visual hallucinations in DLB patients, but there were some issues regarding pharmacotherapy for DLB.