Evaluation of outer nuclear layer overshadowed by retinal vessels in retinitis pigmentosa
Evaluation of outer nuclear layer overshadowed by retinal vessels in retinitis pigmentosa
复制标题
色素性视网膜炎视网膜血管遮蔽外核层的评估
DOI：
10.1038/s41433-021-01578-y
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发表时间：
2021
期刊：
影响因子：
3.9
通讯作者：
Tsujikawa Akitaka
中科院分区：
文献类型：
--
作者：
Otsuka Yuki;Oishi Akio;Miyata Manabu;Uji Akihito;Oishi Maho;Hasegawa Tomoko;Numa Shogo;Ikeda Hanako Ohashi;Tsujikawa Akitaka
ObjectivesWe investigated in vivo light induced photoreceptor damage in retinitis pigmentosa（RP）using spectral-domain optical coherence tomography（SD-OCT）images. Methods We retrospectively reviewed patients with genetic diagnosis ofEYS-associated RP.在SD-OCT垂直扫描上测量视网膜血管下的外核层（ONL）厚度。作为对照，我们测量了距血管上级和下级100 μm的相邻ONL厚度。在健康受试者中进行相同的测量。计算血管下ONL厚度除以相邻ONL厚度平均值的比值，定义为ONL保存率。在RP患者中，椭圆体区（EZ）的长度从中央凹也测量了SD-OCT垂直scans. ResultsThirtyEYS相关RP患者和25名健康受试者。在两组中，被视网膜血管遮蔽的ONL厚度与邻近区域的厚度无显著差异。而RP组上级和下层的ONL保存率均大于健康对照组（分别为1.03和1.15比0.97; p< 0.01）。RP组下视网膜ONL保留率显著高于上级视网膜（p< 0.01）。RP患者下视网膜EZ长度小于上级视网膜EZ长度，差异有统计学意义（p< 0.01）。这些结果表明，纵向环境光暴露可能与感光细胞死亡。
ObjectivesWe investigated in vivo light-induced photoreceptor damage in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) images.MethodsWe retrospectively reviewed patients with genetic diagnosis ofEYS-associated RP. The outer nuclear layer (ONL) thickness under retinal vessels was measured on SD-OCT vertical scans. As a control, we measured adjacent ONL thickness 100 μm superior and inferior from the vessel. Same measurements were performed in healthy subjects. We calculated the ratio of ONL thickness under vessel divided by the average of adjacent ONL thickness and defined as ONL preservation ratio. In patients with RP, the length of ellipsoid zone (EZ) from the fovea was also measured with SD-OCT vertical scans.ResultsThirtyEYS-associated RP patients and 25 healthy subjects were included. In both groups, ONL thickness overshadowed by retinal vessels was not significantly different from that of adjacent area. However, ONL preservation ratio of RP was larger than that of healthy control in both superior and inferior retina (1.03 vs 0.97;p< 0.01, 1.15 vs 0.95;p< 0.01, respectively). In RP, ONL preservation ratio was significantly larger in the inferior retina than superior retina (p< 0.01). Furthermore, in RP patients, the EZ length from the fovea was always shorter in the inferior than superior retina and there was a significant difference (p< 0.01).ConclusionsPatients withEYS-associated RP exhibited inferior-dominant photoreceptor death and the relative ONL preservation under retinal vessels. These results suggest that longitudinal environment light exposure may be correlated with the photoreceptor death.
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影响因子：
4.2
作者：
Bagci, Ahmet Murat;Shahidi, Mahnaz;Ansari, Rashid;Blair, Michael;Blair, Norman Paul;Zelkha, Ruth
通讯作者：
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影响因子：
1.7
作者：
C. Ainsworth;M. Page
通讯作者：
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DOI：
10.1073/pnas.0408892102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Cideciyan, AV;Jacobson, SG;Aguirre, GD
通讯作者：
Aguirre, GD
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影响因子：
82.9
作者：
Alan F. Wright
通讯作者：
Alan F. Wright
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影响因子：
4.4
作者：
Naash,ML;Peachey,NS;Li,ZY;Gryczan,CC;Goto,Y;Blanks,J;Milam,AH;Ripps,H
通讯作者：
Ripps,H