Controlled-release naproxen using micronized ethyl cellulose by wet-granulation and solid-dispersion method
Controlled-release naproxen using micronized ethyl cellulose by wet-granulation and solid-dispersion method
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DOI：
10.1081/ddc-120002445
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发表时间：
2002-01-01
影响因子：
3.4
通讯作者：
Ashraf, M
中科院分区：
文献类型：
--
作者：
Iqbal, Z;Babar, A;Ashraf, M
本研究以乙基纤维素（ethocel）为控释聚合物，制备了萘普生控释片。采用常规湿法制粒法和固体分散法制备制剂。比较两种方法制备的片剂的控释溶出曲线。这两种方法都是有用的，在开发的控释制剂的萘普生具有理想的性能。然而，制备具有所需释放曲线的制剂所需的聚合物的量通过固体分散体比通过湿法制粒少33%。从固体分散体制剂中释放出累积88%的萘普生，而从湿法制粒制剂中释放出84%。
This study has been undertaken to develop a controlled-release tablet dosage form of naproxen using ethocel (ethyl cellulose) as the rate-controlling polymer. The formulations were made by employing the conventional wet-granulation method and the solid-dispersion method. Tablets made by both methods were compared for their controlled-release dissolution profiles. Both methods were useful in developing the controlled-release formulations of naproxen with desirable properties. However, the amount of polymer required to make a formulation with the desired release profile was 33% less via solid dispersion than via wet granulation. A cumulative 88% of naproxen was released from the solid-dispersion formulation, compared with 84% from the wet-granulation formulation.