Protein kinase D signaling: multiple biological functions in health and disease.
Protein kinase D signaling: multiple biological functions in health and disease.
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DOI：
10.1152/physiol.00037.2010
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Rozengurt E
中科院分区：
文献类型：
--
作者：
Rozengurt E
蛋白激酶D（PKD）是一个进化上保守的蛋白激酶家族，具有不同于PKC家族成员的结构、酶学和调节特性。通过PKD的信号传导是由大量的刺激诱导的，包括G蛋白偶联受体激动剂和多肽生长因子。PKD 1是该家族中研究最多的成员，越来越多地参与调节一系列复杂的基本生物学过程，包括信号转导、细胞增殖和分化、膜运输、分泌、免疫调节、心脏肥大和收缩、血管生成和癌症。PKD通过其空间和时间定位的动态变化，结合其独特的底物特异性，介导如此多样的正常和异常生物学功能。迄今为止，对PKD的研究表明其信号产生和分布的惊人多样性及其与多个下游途径的复杂调节相互作用的潜力，通常调节其靶标的亚细胞定位。
Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural, enzymological, and regulatory properties different from the PKC family members. Signaling through PKD is induced by a remarkable number of stimuli, including G protein-coupled receptor agonists and polypeptide growth factors. PKD1, the most studied member of the family, is increasingly implicated in the regulation of a complex array of fundamental biological processes, including signal transduction, cell proliferation and differentiation, membrane trafficking, secretion, immune regulation, cardiac hypertrophy and contraction, angiogenesis and cancer. PKD mediates such diverse array of normal and abnormal biological functions via dynamic changes in its spatial and temporal localization, combined with its distinct substrate specificity. Studies on PKD thus far indicate a striking diversity of both its signal generation and distribution and its potential for complex regulatory interactions with multiple downstream pathways, often regulating the sub-cellular localization of its targets.
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蛋白激酶 D 信号传导在胰腺癌中的作用。
影响因子：
5.8
作者：
Guha, Sushovan;Tanasanvimon, Suebpong;Sinnett-Smith, James;Rozengurt, Enrique
通讯作者：
Rozengurt, Enrique
影响因子：
21.3
作者：
Eiseler T;Döppler H;Yan IK;Kitatani K;Mizuno K;Storz P
通讯作者：
Storz P
DOI：
10.1523/jneurosci.1879-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bisbal M;Conde C;Donoso M;Bollati F;Sesma J;Quiroga S;Díaz Añel A;Malhotra V;Marzolo MP;Cáceres A
通讯作者：
Cáceres A
影响因子：
4.8
作者：
Celil, AB;Campbell, PG
通讯作者：
Campbell, PG
影响因子：
11.2
作者：
Biswas, M. Helal Uddin;Du, Cheng;Balaji, K. C.
通讯作者：
Balaji, K. C.