SPC24 is critical for anaplastic thyroid cancer progression.
SPC24 is critical for anaplastic thyroid cancer progression.
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SPC24对于甲状腺未分化癌的进展至关重要
DOI：
10.18632/oncotarget.15670
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发表时间：
2017-03-28
期刊：
影响因子：
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通讯作者：
Song D
中科院分区：
文献类型：
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作者：
Yin H;Meng T;Zhou L;Chen H;Song D
在过去的20年里，甲状腺癌的发病率在全球范围内迅速上升。间变性甲状腺癌（ATC）是所有甲状腺癌中最致命的，也是最具侵袭性的人类癌症之一。SPC 24是肿瘤发生中有丝分裂检查点机制的重要组成部分，并且在结直肠癌和肝细胞癌中发现了高水平的SPC 24，但其在未分化甲状腺癌中的作用仍不清楚。我们的研究结果表明，SPC 24在人甲状腺癌样品中高表达。此外，敲低内源性SPC 24可抑制不同ATC细胞的生长，抑制细胞侵袭能力，促进细胞凋亡。接下来，体内异种移植物研究表明，与对照相比，SPC 24敲低细胞具有减小的肿瘤尺寸。这一结论也得到了我们使用人类甲状腺癌样本进行的研究的支持。综上所述，我们的数据表明，SPC 24可以作为一个有前途的预后ATC细胞的生物标志物，这是一个新的策略，可以开发的目标SPC 24在未来。
In the past 2 decades, the incidence of thyroid cancer has been rapidly increasing worldwide. Anaplastic thyroid cancer (ATC) is the most lethal of all thyroid cancers and one of the most aggressive human carcinomas. SPC24 is an important component of the mitotic checkpoint machinery in the tumorigenesis and high levels of SPC24 have been found in colorectal and hepatocellular carcinomas, but its role in anaplastic thyroid cancer is still unclear. Our results showed that SPC24 was high expressed in human thyroid cancer samples. In addition, knockingdown endogenous SPC24 could repress cell growth, inhibit cell invasive ability and promote apoptosis in different ATC cells. Next, in vivo xenograft studies indicated that the SPC24 knockdown cells has decreased tumor size compared to the controls. This conclusion is also endorsed by our studies using human thyroid cancer samples. Taken together, our data demonstrates that SPC24 can serve as a promising prognostic biomarker of ATC cells and it is a novel strategy which could be developed by targeting SPC24 in future.