Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.
Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.
复制标题
DOI：
--
复制
发表时间：
1992-12
期刊：
影响因子：
11.2
通讯作者：
B. Teicher;E. Sotomayor;Zhen-Dong Huang
中科院分区：
文献类型：
--
作者：
B. Teicher;E. Sotomayor;Zhen-Dong Huang
血液供应的形成（血管生成）对实体瘤的生长至关重要。天然存在的类固醇四氢皮质醇、合成的环糊精衍生物-环糊精十四硫酸酯和四环素衍生物米诺环素具有抗血管生成活性。四氢皮质醇和β -环糊精十四磺酸按1:1的摩尔比连续输注14天，从Lewis肺癌移植后第4天到第18天，连续14天静脉注射米诺环素，在接受顺式二胺二氯铂（II）、美法兰、环磷酰胺、阿霉素、博来霉素和标准方案放疗后，原发肿瘤的生长延迟明显增加。在细胞毒性治疗中加入抗血管生成药物不仅减少了原发肿瘤形成的肺转移瘤的数量，而且减少了大转移瘤的数量。12只接受抗血管生成调节剂和环磷酰胺治疗的动物中，有5只长期存活（bb0 - 120天）。因此，抗血管生成疗法可以增强标准抗癌疗法的疗效。
The formation of a blood supply (angiogenesis) is critical to the growth of solid tumors. The naturally occurring steroid tetrahydrocortisol, the synthetic cyclodextrin derivative beta-cyclodextrin tetradecasulfate, and the tetracycline derivative minocycline have antiangiogenic activity. Tetrahydrocortisol and beta-cyclodextrin tetradecasulfate in a 1:1 molar ratio by continuous infusion over 14 days and minocycline administered i.p. over 14 days from day 4 to day 18 postimplantation of the Lewis lung carcinoma significantly increased the growth delay of the primary tumor after treatment with cis-diamminedichloroplatinum(II), melphalan, cyclophosphamide, Adriamycin, bleomycin, and radiation therapy administered in standard regimens. Addition of the antiangiogenic agents to treatment with the cytotoxic therapies not only reduced the number of lung metastases formed from the primary tumor but also reduced the number of large metastases. Five of 12 animals treated with the antiangiogenic modulators and cyclophosphamide were long-term survivors (> 120 days). Thus, antiangiogenic therapies can potentiate the efficacy of standard anticancer therapies.