Pyrazine chemistry. II. Reduction of 3,6-Dibenzylidenepiperazine-2,5-diones
Pyrazine chemistry. II. Reduction of 3,6-Dibenzylidenepiperazine-2,5-diones
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吡嗪化学。
DOI：
10.1071/ch9841791
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发表时间：
1985
影响因子：
1.1
通讯作者：
J. Elix
中科院分区：
文献类型：
--
作者：
S. Marcuccio;J. Elix
对用锌和乙酸还原3，6-二亚苄基哌嗪-2，5-二酮（1）的再研究表明，该反应得到（Z）-6-苄基-3-亚苄基哌嗪-2，5-二酮（10）。当在还原中使用乙酸和盐酸的混合物时，得到反式-（12）和顺式-3，6-二苄基哌嗪-2，5-二酮（5）的混合物。3，6-二（2-氯亚苄基）哌嗪-2，5-二酮（2）直接催化还原为（±）-顺式-3，6-二（2-氯苄基）哌嗪-2，5-二酮（6）。
A reinvestigation of the reduction of 3,6-dibenzylidenepiperazine-2,5-dione (1) with zinc and acetic acid established that this reaction gave (Z)-6-benzyl-3-benzylidenepiperazine-2,5-dione (10). When a mixture of acetic acid and hydrochloric acid was used in the reduction, a mixture of trans- (12) and cis-3,6-dibenzylpiperazine-2,5-dione (5) was obtained. Direct catalytic reduction of 3,6-di(2-chloro- benzy1idene)piperazine-2,5-dione (2) to (±)-cis-3,6-di(2-chlorobenzyl)piperazine-2,5-dione (6) was also accomplished.