RECTAL DOSE AND SOURCE STRENGTH OF THE HIGH-DOSE-RATE IRIDIUM-192 BOTH AFFECT LATE RECTAL BLEEDING AFTER INTRACAVITARY RADIATION THERAPY FOR UTERINE CERVICAL CARCINOMA
RECTAL DOSE AND SOURCE STRENGTH OF THE HIGH-DOSE-RATE IRIDIUM-192 BOTH AFFECT LATE RECTAL BLEEDING AFTER INTRACAVITARY RADIATION THERAPY FOR UTERINE CERVICAL CARCINOMA
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DOI：
10.1016/j.ijrobp.2009.05.030
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发表时间：
2010-07-01
影响因子：
7
通讯作者：
Inoue, Takehiro
中科院分区：
文献类型：
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作者：
Isohashi, Fumiaki;Yoshioka, Yasuo;Inoue, Takehiro
目的：本研究的目的是再次证实我们以前的发现，直肠剂量和源强度都影响高剂量率腔内近距离放射治疗后的晚期直肠出血（人类发展报告-国际生物技术和生物多样性公约），通过使用根据国际辐射单位和测量报告委员会（ICRU（RP））或剂量体积直方图（DVH）的定义计算的直肠剂量方法和材料：62例接受HDR-ICBT并随访1年或更长时间的患者进行了研究。ICBT的直肠剂量是通过使用基于正交射线照片的ICRP（RP）或基于计算机断层扫描（CT）的DVH参数计算的。总剂量计算为以2-戈伊分数表示的生物等效剂量（EQD（2））。结果：根据直肠EQD（2）（>=或=或= 0）将患者分为4组时，直肠EQD（2）（>= 0）和直肠EQD（2）（>= 0）与晚期直肠出血的发生率无显著性差异（P> 0.05），直肠EQD（2）（>= 0）与晚期直肠出血的发生率无显著性差异（P> 0.05）。
Purpose: The purpose of this study was to reconfirm our previous findings that the rectal dose and source strength both affect late rectal bleeding after high-dose-rate intracavitary brachytherapy (HDR-ICBT), by using a rectal dose calculated in accordance with the definitions of the International Commission on Radiation Units and Measurements Report 38 (ICRU(RP)) or of dose volume histogram (DVH) parameters by the Groupe Europeen de Curietherapie of the European Society for Therapeutic Radiology and Oncology.Methods and Materials: Sixty-two patients who underwent HDR-ICBT and were followed up for 1 year or more were studied. The rectal dose for ICBT was calculated by using the ICRP(RP) based on orthogonal radiographs or the DVH parameters based on computed tomography (CT). The total dose was calculated as the biologically equivalent dose expressed in 2-Gy fractions (EQD(2)). The relationship between averaged source strength or the EQD(2) and late rectal bleeding was then analyzed.Results: When patients were divided into four groups according to rectal EQD(2) (>= or = or