Highly enantioselective synthesis of α-fluoro-α-nitro esters via organocatalyzed asymmetric Michael addition
Highly enantioselective synthesis of α-fluoro-α-nitro esters via organocatalyzed asymmetric Michael addition
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DOI：
10.1016/j.tet.2010.11.041
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发表时间：
2011-01-14
期刊：
影响因子：
2.1
通讯作者：
Zhao, Gang
中科院分区：
文献类型：
--
作者：
Cui, Hai-Peng;Li, Peng;Zhao, Gang
伯胺催化2-氟-2-硝基乙酸乙酯与烯酮的不对称迈克尔加成反应，得到具有两个连续立体中心的手性α-氟-α-硝基酯酮，其中一个是氟化季手性中心，具有优异的对映选择性和中等至良好的产率。 Crown 版权所有 (C) 2010 由 Elsevier Ltd 出版。保留所有权利。
Primary amines catalyzed the asymmetric Michael addition of ethyl 2-fluoro-2-nitroacetate to enones to provide chiral alpha-fluoro-alpha-nitro ester ketones with two contiguous stereogenic centers, one of which is a fluorinated quaternary chiral center, with excellent enantioselectivities and in moderate to good yields. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.