Non-uniform radiation-induced biological responses at the tissue level involved in the health risk of environmental radiation: a radiobiological hypothesis
Non-uniform radiation-induced biological responses at the tissue level involved in the health risk of environmental radiation: a radiobiological hypothesis
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DOI：
10.1186/s12940-018-0444-4
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发表时间：
2018-12-29
影响因子：
6
通讯作者：
Prise, Kevin M.
中科院分区：
文献类型：
--
作者：
Fukunaga, Hisanori;Prise, Kevin M.
背景辐射防护的传统概念基于辐射流行病学研究，支持剂量与反应之间的正相关性。然而，组织水平上的生物反应存在显着差异，具体取决于由于组织保护效应 (TSE) 导致辐射是均匀分布还是非均匀时空分布。从辐射微剂量测定的角度来看，环境辐射以非均匀分布的形式传递，组织水平上的辐射引起的生物反应，例如TSE，将与环境辐射暴露后的个体风险有关。假设我们假设，由于辐射后的TSE，非均匀辐射暴露的健康风险低于均匀暴露的相同剂量的健康风险。检验这一假设需要使用高精度微束进行放射生物学研究以及环境辐射引起的影响的流行病学数据。该假设的影响将导致环境辐射防护领域更加个性化的方法。结论时空剂量分布的检测对于更准确地评估个人环境辐射暴露风险具有重要的科学意义。预计将在组织水平上对非均匀辐射引起的生物反应进行进一步的放射生物学研究。
BackgroundThe conventional concept of radiation protection is based on epidemiological studies of radiation that support a positive correlation between dose and response. However, there is a remarkable difference in biological responses at the tissue level, depending on whether radiation is delivered as a uniform or non-uniform spatiotemporal distribution due to tissue sparing effects (TSE). From the point of view of radiation micro-dosimetry, environmental radiation is delivered as a non-uniform distribution, and radiation-induced biological responses at the tissue level, such as TSE, would be implicated in individual risk following exposure to environmental radiation.HypothesisWe hypothesize that the health risks of non-uniform radiation exposure are lower than the same dose at a uniform exposure, due to TSE following irradiation. Testing the hypothesis requires both radiobiological studies using high-precision microbeams and the epidemiological data of environmental radiation-induced effects. The implications of the hypothesis will lead to more personalized approaches in the field of environmental radiation protection.ConclusionThe detection of spatiotemporal dose distribution could be of scientific importance for more accurate individual risk assessment of exposure to environmental radiation. Further radiobiological studies on non-uniform radiation-induced biological responses at the tissue level are expected.