Chemokines and the molecular basis of cancer metastasis.
Chemokines and the molecular basis of cancer metastasis.
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DOI：
10.1056/nejm200109133451113
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发表时间：
2001-09-13
影响因子：
158.5
通讯作者：
Murphy, PM
中科院分区：
文献类型：
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作者：
Murphy, PM
转移是大多数癌症发病和死亡的主要原因。适当地，“癌症”（来自拉丁语的“螃蟹”）和“转移”（来自希腊语的“位置变化”）都指细胞运动：癌症像螃蟹一样侵入健康组织，癌细胞迁移到远离原发性肿瘤的部位。自从100多年前佩吉特的工作以来，病理学家已经认识到癌细胞的运动不是随机的，不同类型的癌症有不同的目的地。为了解释这种特殊性，“土壤和种子”理论指出，不同的器官......
Metastasis is the chief cause of morbidity and mortality in most cancers. Appropriately, the words “cancer” (from the Latin for “crab”) and “metastasis” (from the Greek for “change in position”) both refer to cell movement: the crab-like invasion of cancer into healthy tissue and the migration of cancer cells to sites distant from the primary tumor. Since the work of Paget more than 100 years ago, pathologists have recognized that the movement of cancer cells is not random and that different types of cancer have different destinations. To explain this specificity, the “soil and seed” theory states that different organs . . .